Evidence map›Paper›PMID 31876154›Full record

ArticleACS infectious diseases2020

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.

Tsutomu Akama, Yvonne R Freund, Pamela W Berry, David S Carter, Eric E Easom, Kurt Jarnagin, Christopher S Lunde, Jacob J Plattner, Fernando Rock, Rianna Stefanakis and 17 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Tsutomu AkamaAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Yvonne R FreundAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Pamela W BerryAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
David S CarterAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Eric E EasomAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Kurt JarnaginAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Christopher S LundeAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Jacob J PlattnerAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Fernando RockAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Rianna StefanakisAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.
Chelsea FischerDepartment of Pharmaceutical Chemistry , University of California San Francisco , 1700 4th Street , San Francisco , California 94158 , United States.
Christina A BulmanDepartment of Pharmaceutical Chemistry , University of California San Francisco , 1700 4th Street , San Francisco , California 94158 , United States.
Kee Chong LimDepartment of Pharmaceutical Chemistry , University of California San Francisco , 1700 4th Street , San Francisco , California 94158 , United States.
Brian M SuzukiSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093-0657 , United States.
Nancy TricocheLindsley F. Kimball Research Institute , New York Blood Center , 310 E. 67th Street , New York , New York 10065 , United States.
Abdelmoneim MansourTRS Laboratories, Inc. , 295 Research Drive , Athens , Georgia 30605 , United States.
Utami DiCostyTRS Laboratories, Inc. , 295 Research Drive , Athens , Georgia 30605 , United States.
Scott McCallTRS Laboratories, Inc. , 295 Research Drive , Athens , Georgia 30605 , United States.
Ben CarsonTRS Laboratories, Inc. , 295 Research Drive , Athens , Georgia 30605 , United States.
John W McCallTRS Laboratories, Inc. , 295 Research Drive , Athens , Georgia 30605 , United States.
James McKerrowSkaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093-0657 , United States.
Marc P HübnerInstitute for Medical Microbiology, Immunology and Parasitology , University Hospital Bonn , Sigmund Freud Strasse 25 , 53127 Bonn , Germany.
Sabine SpechtInstitute for Medical Microbiology, Immunology and Parasitology , University Hospital Bonn , Sigmund Freud Strasse 25 , 53127 Bonn , Germany.
Achim HoeraufInstitute for Medical Microbiology, Immunology and Parasitology , University Hospital Bonn , Sigmund Freud Strasse 25 , 53127 Bonn , Germany.
Sara LustigmanLindsley F. Kimball Research Institute , New York Blood Center , 310 E. 67th Street , New York , New York 10065 , United States.
Judy A SakanariDepartment of Pharmaceutical Chemistry , University of California San Francisco , 1700 4th Street , San Francisco , California 94158 , United States.ORCID 0000-0003-3895-2982
Robert T JacobsAnacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle , Palo Alto , California 94303 , United States.ORCID 0000-0001-9669-2862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of benzimidazole-benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good

Indexed as

AmidesAnimalsBenzimidazolesBoron CompoundsBrugiaFemaleFilaricidesGerbillinaeMaleOnchocerca volvulusOnchocerciasisAmidesBenzimidazolesBoron CompoundsFilaricidesflubendazolelymphatic filariasisonchocerciasisorganoborontubulin

Identifiers

PMID31876154
PMCPMC7026885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.