Evidence map›Paper›PMID 31876118›Full record

Trial reportInternational wound journal2020

Nano-hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study.

Giuseppe Gallelli, Erika Cione, Raffaele Serra, Antonio Leo, Rita Citraro, Pietro Matricardi, Chiara Di Meo, Francesco Bisceglia, Maria C Caroleo, Sonia Basile and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International wound journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 107 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Giuseppe GallelliDivision of Vascular surgery, Department of Sugery, Pugliese Hospital, Catanzaro, Italy.
Erika CioneDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Raffaele SerraDepartment of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.
Antonio LeoDepartment of Health Sciences, University of Catanzaro, Catanzaro, Italy.
Rita CitraroDepartment of Health Sciences, University of Catanzaro, Catanzaro, Italy.
Pietro MatricardiDepartment of Drug Chemistry and Technologies, Sapienza University of Roma, Rome, Italy.
Chiara Di MeoDepartment of Drug Chemistry and Technologies, Sapienza University of Roma, Rome, Italy.
Francesco BiscegliaDepartment of Health Sciences, University of Catanzaro, Catanzaro, Italy.
Maria C CaroleoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Sonia BasileDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Luca GallelliDepartment of Health Sciences, University of Catanzaro, Catanzaro, Italy.
Azienda Ospedaliero Universitario Mater Domini · ITUniversity of Calabria · ITSapienza University of Rome · ITAzienda Ospedaliera Pugliese Ciaccio · ITMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing, especially diabetic ones, is a relevant clinical problem, so it is not surprising that surgical procedures are often needed. To overcome invasive procedures, several strategies with drugs or natural compound are used. Recently, in an experimental study, we described an increase in keratinocyte proliferation after their exposition to quercetin plus oleic acid. In the present clinical study, we evaluated both the clinical efficacy and the safety of nano-hydrogel embedded with quercetin and oleic acid in the treatment of lower limb skin wound in patients with diabetes mellitus (DM). Fifty-six DM patients (28 men and 28 women, mean age 61.7 ± 9.2 years) unsuccessfully treated with mechanical compression were enrolled and randomised to receive an add on treatment with hyaluronic acid (0.2%) or nano-hydrogel embedded with quercetin and oleic acid. The treatment with nano-hydrogel embedded with quercetin and oleic acid significantly (P < .01) reduced the wound healing time, in comparison to hyaluronic acid (0.2%) without developing of adverse drug reactions, suggesting that this formulation could be used in the management of wound healing even if other clinical trials must be performed in order to validate this observation.

Indexed as

Wound HealingAgedAntioxidantsDiabetic FootDrug CombinationsFemaleFollow-Up StudiesHumansHydrogelsMaleMiddle AgedOleic AcidPilot ProjectsProspective StudiesQuercetinAntioxidantsDrug CombinationsHydrogelsOleic AcidQuercetinhyaluronic acidnano-hydrogeloleic acidquercetinwound healing

Identifiers

PMID31876118
PMCPMC7948574
OpenAlexW2997187699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.