Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2020
Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Opportunities and challenges with artificial intelligence in allergy and immunology: a bibliometric study.Frontiers in medicine · 2025Pooled it
- Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Trial
- Joint modelling of wheeze and lung function from childhood to early adulthood: four population-based birth cohorts.EClinicalMedicine · 2026Article
- Clustering lung function and symptom profiles for asthma risk stratification.Scientific reports · 2025Article
- Profile of mild/moderate asthma patients: Baseline data from the MANI cohort.The World Allergy Organization journal · 2025Article
- Patterns of Respiratory Symptoms and Asthma Diagnosis in School-Age Children: Three Birth Cohorts.Allergy · 2025Article
- ERS Congress 2024: highlights from the Paediatrics Assembly.ERJ open research · 2025Article
- Mechanistic modelling of allergen-induced airways disease in early life.Scientific reports · 2025Article
- Social inequalities in childhood asthma.The World Allergy Organization journal · 2024Review
- Exploring Machine Learning Applications in Pediatric Asthma Management: Scoping Review.JMIR AI · 2024Article
- Artificial intelligence and wheezing in children: where are we now?Frontiers in medicine · 2024Review
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- Burden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort.Respiratory research · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Poor Asthma Control in Schoolchildren May Lead to Lower Lung Function Trajectory from Childhood to Early Adulthood: A Japanese Cohort Study.Journal of asthma and allergy · 2022Article
- Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes.American journal of respiratory and critical care medicine · 2021Article
- Improvement in Asthma Symptoms and Pulmonary Function in Children After SARS-CoV-2 Outbreak.Frontiers in pediatrics · 2021Article
- Preschool Wheezing: Trajectories and Long-Term Treatment.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionExacerbation-prone asthma subtype has been reported in studies using data-driven methodologies. However, patterns of severe exacerbations have not been studied.
objectiveTo investigate longitudinal trajectories of severe wheeze exacerbations from infancy to school age.
methodsWe applied longitudinal k-means clustering to derive exacerbation trajectories among 887 participants from a population-based birth cohort with severe wheeze exacerbations confirmed in healthcare records. We examined early-life risk factors of the derived trajectories, and their asthma-related outcomes and lung function in adolescence.
results498/887 children (56%) had physician-confirmed wheeze by age 8 years, of whom 160 had at least one severe exacerbation. A two-cluster model provided the optimal solution for severe exacerbation trajectories among these 160 children: "Infrequent exacerbations (IE)" (n = 150, 93.7%) and "Early-onset frequent exacerbations (FE)" (n = 10, 6.3%). Shorter duration of breastfeeding was the strongest early-life risk factor for FE (weeks, median [IQR]: FE, 0 [0-1.75] vs. IE, 6 [0-20], P < .001). Specific airway resistance (sR
conclusionWe have identified two distinct trajectories of severe exacerbations during childhood with different early-life risk factors and asthma-related outcomes in adolescence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.