ArticleBrain and behavior2020
Retinal sublayer defect is independently associated with the severity of hypertensive white matter hyperintensity.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Ultra-widefield OCTA assessment of retinal and choroidal microcirculation in cerebral small vessel disease.Scientific reports · 2026Article
- Relationships between multimodal ocular imaging and white matter hyperintensity volume.Quantitative imaging in medicine and surgery · 2025Article
- Ophthalmic Artery Morphology and Hemodynamics Associated with White Matter Hyperintensity.International journal of medical sciences · 2024Article
- Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission.Scientific reports · 2022Article
- Characterization of Macular Structural and Microvascular Changes in Thalamic Infarction Patients: A Swept-Source Optical Coherence Tomography-Angiography Study.Brain sciences · 2022Article
- Retinal thickness changes in different subfields reflect the volume change of cerebral white matter hyperintensity.Frontiers in neurology · 2022Article
- Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions.Sensors (Basel, Switzerland) · 2021Article
- Assessment of the outer retina and choroid in white matter lesions participants using swept-source optical coherence tomography.Brain and behavior · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Neuroretinal Biomarkers for Schizophrenia Spectrum Disorders.Translational vision science & technology · 2021Article
- Outer Retinal Layer Thickness Changes in White Matter Hyperintensity and Parkinson's Disease.Frontiers in neuroscience · 2021Article
- Retinal sublayer defect is independently associated with the severity of hypertensive white matter hyperintensity.Brain and behavior · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) imaging with brain magnetic resonance imaging (MRI) markers using the Fazekas scale in hypertensive white matter hyperintensity (WMH) subjects.
methodsEighty-eight participants (32 healthy controls and 56 hypertensive white matter hyperintensity subjects) underwent retinal imaging using the OCT and MRI. A custom-built algorithm was used to measure the thicknesses of the retinal nerve fiber layer (RNFL) and ganglion cell layer and inner plexiform layer (GCIP). Focal markers for white matter hyperintensities were assessed on MRI and graded using the Fazekas visual rating.
resultsHypertensive WMH showed significantly reduced (p < .05) RNFL and GCIP layers when compared to healthy controls, respectively. A significant correlation was found between the RNFL (ρ = -.246, p < .001) and GCIP (ρ = -.338, p < .001) of the total participants and the Fazekas score, respectively. Statistical differences were still significant (p < .05) when correlations were adjusted for intereye correlation, age, hypertension, smoking, body mass index, and diabetes. Among the cases of hypertensive WMH, higher Fazekas scores were significantly associated (p < .05) with the thinning of both the RNFL and GCIP layers after adjustment of age and other risk factors.
conclusionsRetinal degeneration in the RNFL and GCIP was independently associated with focal lesions in the white matter of the brain and deteriorates with the severity of the lesions. We suggest that imaging and measurement of the retinal sublayers using the OCT may provide evidence on neurodegeneration in WMH.
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