Evidence map›Paper›PMID 31875639›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis.

Kenji Sawada, Atsushi Takai, Tomoyo Yamada, Osamu Araki, Yuki Yamauchi, Yuji Eso, Ken Takahashi, Takero Shindo, Takaki Sakurai, Yoshihide Ueda and 1 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kenji SawadaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Atsushi TakaiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Tomoyo YamadaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Osamu ArakiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Yuki YamauchiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Yuji EsoDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Ken TakahashiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Takero ShindoDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Takaki SakuraiDepartment of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Japan.
Yoshihide UedaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Hiroshi SenoDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis.

Indexed as

AdultAnemia, AplasticDisease ProgressionHepatitisHumansImmunosuppressive AgentsLiver CirrhosisMaleImmunosuppressive Agentshepatitis-associated aplastic anemialiver fibrosis

Identifiers

PMID31875639
PMCPMC7205540
OpenAlexW2998013912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.