SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Prognostic value of coronary flow reserve in patients with suspected or known coronary artery disease referred to PET myocardial perfusion imaging: A meta-analysis.
Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- ESR Essentials: imaging in stable chest pain - practice recommendations by ESCR.European radiology · 2024Guideline
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Long term prognostic value of coronary atherosclerotic burden, myocardial perfusion and coronary flow capacity byEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Vessel-specific perivascular fat attenuation index derived from AI-CCTA and its association with impaired coronary flow reserve in patients with INOCA.International journal of cardiology. Heart & vasculature · 2026Article
- Prognostic interplay between cardiac allograft vasculopathy and coronary vascular function by hybrid rubidium-82 PET/CT imaging in heart transplant population.European journal of nuclear medicine and molecular imaging · 2026Article
- Cardiovascular Imaging in Psoriasis: A Critical Review of Current Evidence, Techniques, and Therapeutic Implications.American journal of clinical dermatology · 2026Review
- Myocardial blood flow reference values for 13N-ammonia PET myocardial perfusion imaging in patients without flow-limiting coronary artery disease.European journal of nuclear medicine and molecular imaging · 2025Article
- What role for cardiac imaging in chronic coronary syndromes: review of the literature in light of the latest recommendations.European heart journal. Imaging methods and practice · 2025Review
- Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2025Article
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Coronary vascular dysfunction is associated with increased risk of death in patients with peripheral artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Exploring coronary microvascular function by quantitative CZT-SPECT: a small step or giant leap for INOCA patients?European journal of nuclear medicine and molecular imaging · 2023Article
- Interaction of impaired myocardial flow reserve and extent of myocardial ischemia assessed usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Including myocardial flow reserve by PET in prediction models: Ready to fly?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Incremental prognostic value of positron emission tomography derived left ventricular mass.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Reduced acquisition time for thallium myocardial perfusion imaging with large field cadmium-zinc-telluride SPECT/CT cameras: An equivalence study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Scintillation cameras: A new clinical era has come.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve.Microvascular research · 2021Article
- Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease byDiagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe performed a meta-meta-analysis to evaluate the prognostic value of coronary flow reserve (CFR) assessed by cardiac positron emission tomography (PET) imaging in patients with suspected or known coronary artery disease (CAD).
methodsStudies published until April 2019 were identified by database search. We included studies if they evaluated CFR by PET providing data on adjusted hazard ratio (HR) for the occurrence of adverse events. Annualized event rates were calculated and the incidence rate ratios with 95% confidence interval (CI) were estimated to compare patients with impaired and preserved CFR.
resultsWe identified 13 eligible articles including 11,867 patients with a follow-up ranging from 0.6 to 7.1 years. The HR for the occurrence of major adverse cardiac events (MACE) was reported in 11 studies and pooled HR was 1.93 (95% CI 1.65-2.27). The HR for the occurrence of hard events was reported in 5 studies and pooled HR was 3.11 (95% CI 1.88-5.14). Six studies reported data useful to calculate separately the incidence rate of MACE in patients with preserved and impaired CFR and pooled IRR was 2.26 (CI 95% 1.79-2.85). Three studies reported data useful to calculate separately the incidence rate of hard events in patients with preserved and impaired CFR and pooled IRR was 4.12 (CI 95% 3.08-5.51). At meta-regression analysis, we found an association between HR for MACE and gender, diabetes and hypertension, while no significant association was found between HR for hard events and demographic and clinical variables.
conclusionIn patients with suspected or known CAD, an impaired CFR is associated with adverse cardiovascular events. However, the large heterogeneity in study population underlines the need for further investigations to maximize the prognostic role of CFR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.