Evidence map›Paper›PMID 31875271›Full record

ArticleEcoHealth2020

Monkeypox Rash Severity and Animal Exposures in the Democratic Republic of the Congo.

Reena H Doshi, Vivian H Alfonso, Douglas Morier, Nicole A Hoff, Cyrus Sinai, Prime Mulembakani, Neville Kisalu, Alvan Cheng, Hayley Ashbaugh, Adva Gadoth and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in EcoHealth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  6. From neglected to notoriety: a review of Mpox clinical features, virology, epidemiology, treatment and prevention strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Reena H DoshiDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Vivian H AlfonsoDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Douglas MorierDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Nicole A HoffDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Cyrus SinaiDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Prime MulembakaniKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Neville KisaluVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Alvan ChengDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Hayley AshbaughDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Adva GadothDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
Brian CowellTexas A&M School of Public Health, College Station, TX, USA.
Emile W OkitolondaKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Jean-Jacques Muyembe-TamfumInstitut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
Anne W RimoinDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA. arimoin@ucla.edu.
Fielding Graduate University · USUniversity of California, Los Angeles · USMinistry of Public Health · CDNational Institute of Allergy and Infectious Diseases · USNational Institute of Biomedical Research · CDTexas A&M Health Science Center · US

Funding

Emergence of Human Monkeypox in Central AfricaK01AI074810 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RIMOIN, ANNE WALSH · 2008 to 2012
$609k
NIAID NIH HHS K01 AI074810
6 · The paper itself

Abstract

Experimental studies have suggested a larger inoculum of monkeypox virus may be associated with increased rash severity; however, little data are available on the relationship between specific animal exposures and rash severity in endemic regions. Using cross-sectional data from an active surveillance program conducted between 2005 and 2007 in the Sankuru Province of the Democratic Republic of the Congo, we explored the possible relationship between rash severity and exposures to rodents and non-human primates among confirmed MPX cases. Among the 223 PCR-confirmed MPX cases identified during active surveillance, the majority of cases (n = 149) presented with mild rash (5-100 lesions) and 33% had a more serious presentation (> 100 lesions). No association between exposure to rodents and rash severity was found in the multivariable analysis. Those that self-reported hunting NHP 3 weeks prior to onset of MPX symptoms had 2.78 times the odds of severe rash than those that did not report such exposure (95% CI: 1.18, 6.58). This study provides a preliminary step in understanding the association between animal exposure and rash severity and demonstrates correlation with exposure to NHPs and human MPX presentation. Additional research exploring the relationship between rash severity and NHPs is warranted.

Indexed as

AnimalsCross-Sectional StudiesDemocratic Republic of the CongoExanthemaFemaleHumansMaleMonkeypox virusMpox, MonkeypoxPolymerase Chain ReactionViral ZoonosesAnimal exposureMonkeypoxRash illnessRash severity

Identifiers

PMID31875271
OpenAlexW2997112947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.