Evidence map›Paper›PMID 31875249›Full record

ArticleArchives of gynecology and obstetrics2020

Analysis of HPV genotype-specific concordance between EUROArray HPV and HPV 3.5 LCD-Array Kit in cervical samples of 163 patients.

Karen Bräutigam, Claudia Ehret, Verena Schillinger, Sascha Baum, Maximilian Klar, Frank Köster, Achim Rody, Marcus Panning

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In one paragraph

Article in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karen BräutigamDepartment of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, University of Lübeck, MFC VIII, Maria-Goeppert-Str. 9a, Campus Lübeck, 23562, Lübeck, Germany. karen.braeutigam@uksh.de.ORCID http://orcid.org/0000-0001-8521-9607
Claudia EhretFaculty of MedicineInstitute of Virology, University Medical Center-University of Freiburg, Freiburg, Germany.
Verena SchillingerFaculty of MedicineInstitute of Virology, University Medical Center-University of Freiburg, Freiburg, Germany.
Sascha BaumDepartment of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, University of Lübeck, MFC VIII, Maria-Goeppert-Str. 9a, Campus Lübeck, 23562, Lübeck, Germany.
Maximilian KlarDepartment of Obstetrics and Gynecology, Faculty of Medicine, University Medical Center-University of Freiburg, Freiburg, Germany.
Frank KösterDepartment of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, University of Lübeck, MFC VIII, Maria-Goeppert-Str. 9a, Campus Lübeck, 23562, Lübeck, Germany.
Achim RodyDepartment of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, University of Lübeck, MFC VIII, Maria-Goeppert-Str. 9a, Campus Lübeck, 23562, Lübeck, Germany.
Marcus PanningFaculty of MedicineInstitute of Virology, University Medical Center-University of Freiburg, Freiburg, Germany.
University of Freiburg · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHuman papilloma virus (HPV) as the most common viral infection of the anogenital tract is highly associated with intraepithelial neoplasia and cancer of the cervix and other anogential regions. To date, 15 high-risk (HR-) HPV and 3 probably/possibly HR-HPVs have been found to be associated with cervical cancer. Therefore, a screening especially for HR-HPV by appropriate tests is important for detection of precancerous lesions to prevent cancer. The purpose of this study was to analyze prospectively the concordance of the EUROArray HPV genotyping assay (Euroimmun; EUROArray) and the HPV 3.5 LCD-Array Kit (Chipron; LCD-Array).

methodsLiquid-based, clinician-collected cervical cytology samples (n = 163) from women undergoing cervical inspection at the dysplasia consultation in the colposcopy clinic at the Medical Center-University of Freiburg, Germany were analyzed. Genotype-specific agreement was assessed by Cohen's kappa statistic and McNemar's P value of significance between proportions.

resultsSeventeen of the HR-HPV genotypes included in both assays were detected in 42.3% and 38% of samples by EUROArray and by LCD-Array, respectively; i.e. an agreement of 92.0% and a kappa value of 0.83 could be proven between the EUROArray and the LCD-Array. In 50 of 72 samples, identical HR-HPV genotypes were analyzed (81.9%, κ = 0.47) and genotyping for HPV 16 and/or 18 was highly concordant in both tests (relative agreement 96.3%, κ = 0.88). Detection of any HR-HPV was not significantly different after comparison of EUROArray with LCD-Array.

conclusionBoth of the tests showed comparable results for the detection of HPV in cervical specimens and permit these assays to be suitable for routine diagnostics.

Indexed as

AdultFemaleGenotypeHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsProspective StudiesUterine Cervical NeoplasmsGenital tractHPVTest statisticsVirus classification

Identifiers

PMID31875249
OpenAlexW2997412773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.