Evidence map›Paper›PMID 31875244›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT.

Wouter van der Bruggen, Marlous Hagelstein-Rotman, Lioe-Fee de Geus-Oei, Frits Smit, P D Sander Dijkstra, Natasha M Appelman-Dijkstra, Dennis Vriens

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Validation of quantitative [Annals of nuclear medicine · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Use of bone-SPECT/CT and Na[Frontiers in nuclear medicine · 2025
    Review
  10. [Biomolecules · 2024
    Review
  11. Article
  12. JBMR plus · 2024
    Article
  13. Lesion Expansion in Gnathic Fibrous Dysplasia: Natural History, Indicators of Progression, and Response to Bisphosphonates.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  14. Observational
  15. Article
  16. Denosumab for craniofacial fibrous dysplasia: duration of efficacy and post-treatment effects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  17. Safety of therapy with and withdrawal from denosumab in fibrous dysplasia and McCune-Albright syndrome: an observational study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wouter van der BruggenSection of Nuclear Medicine, dept. of Radiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. w.van.der.bruggen@slingeland.nl.ORCID 0000-0002-4689-6506
Marlous Hagelstein-RotmanCenter for Bone Quality, Department of Internal Medicine, division of Endocrinology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Lioe-Fee de Geus-OeiSection of Nuclear Medicine, dept. of Radiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Frits SmitSection of Nuclear Medicine, dept. of Radiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
P D Sander DijkstraCenter for Bone Quality, Department of Internal Medicine, division of Endocrinology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Natasha M Appelman-DijkstraCenter for Bone Quality, Department of Internal Medicine, division of Endocrinology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Dennis VriensSection of Nuclear Medicine, dept. of Radiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo quantify Na

methodsIn a prospective cohort study (n = 20), Na

resultsPhysiological bone standardized uptake value (SUV) was best normalized but displayed large interpatient variation (total range 4.1-13.7 g/mL), with very high interobserver agreement (ICC = 0.964). FD burden defined by patient-specific SUV cutoffs reached near-perfect agreement for SUVpeak (ICC = 0.994) and total lesion fluorination (TLF) (ICC = 0.999). TLF correlated weakly with SBS (R

conclusionsIndividualized Na

Indexed as

Fibrous Dysplasia of BonePositron Emission Tomography Computed TomographyFibroblast Growth Factor-23HumansPositron-Emission TomographyProspective StudiesReproducibility of ResultsSodium FluorideFGF23 protein, humanFibroblast Growth Factor-23Sodium FluorideBisphosphonatesFibrous dysplasiaReproducibilitySerum biomarkersSodium fluoride PET/CT

Identifiers

PMID31875244
OpenAlexW2995335056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.