ArticleAbdominal radiology (New York)2020
T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis.
Article in Abdominal radiology (New York), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04626492 (Clinical Study on the Value of Quantitative MRI Imaging in Diffuse Liver Diseases), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study on the Value of Quantitative MRI Imaging in Diffuse Liver Diseases
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy and clinical impact of MRI-based technologies for patients with non-alcoholic fatty liver disease: systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2023Pooled it
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- Quantitative MRI mapping parameters to differentiate HER2-positive and HER2-low breast cancer.Quantitative imaging in medicine and surgery · 2026Article
- Scan-rescan reproducibility and interobserver reliability of T1 and T2 measurements of extraocular muscles using a multi-dynamic multi-echo MRI sequence.BMC medical imaging · 2026Article
- Clinical feasibility of accelerated whole liver water TEuropean radiology experimental · 2026Article
- Navigator motion-resolved MR fingerprinting using implicit neural representation: Feasibility for free-breathing three-dimensional whole-liver multiparametric mapping.Magnetic resonance in medicine · 2026Article
- Unraveling Puerarin's impact on MRI hepatic lipid deposition and serum lipids in IUGR offspring rats.PloS one · 2026Article
- Abdominal simultaneous 3D water TMagnetic resonance in medicine · 2026Article
- Summary from the 2025 International Society for Magnetic Resonance in Medicine workshop on body MRI: Unsolved problems and unmet needs.Magnetic resonance in medicine · 2026Review
- An explanation for why tissues with T2 of around 70 milliseconds always measure low MRI apparent diffusion coefficient (ADC).Quantitative imaging in medicine and surgery · 2025Article
- Quantitative Assessment of Liver Fibrosis: B1 Inhomogeneity-Corrected VFA T1 Mapping on Gadobenate Dimeglumine-Enhanced MRI.Current medical imaging · 2025Article
- Evaluation of liver fibrosis staging in patients with chronic hepatitis via the gadolinium washout rate: a comparative study with magnetic resonance elastography and pathology.Quantitative imaging in medicine and surgery · 2025Article
- The Utility of Mesenteric T1 Mapping on MR Enterography in Crohn's Disease: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2025Article
- Automated quantification of T1 and T2 relaxation times in liver mpMRI using deep learning: a sequence-adaptive approach.European radiology experimental · 2025Article
- Estimating liver cirrhosis severity with extracellular volume fraction by spectral CT.Scientific reports · 2025Article
- Comparison of test-retest repeatability of DESPOT and 3D-QALAS for TQuantitative imaging in medicine and surgery · 2025Article
- Influence of fat on hepatic T2 relaxation time estimation: a preliminary investigation.Abdominal radiology (New York) · 2025Article
- Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome.Scientific reports · 2025Article
- Acquisition Efficiency and Technical Repeatability of Dual-Frequency 3D Vector MR Elastography of the Liver.Journal of magnetic resonance imaging : JMRI · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare liver stiffness measurements obtained from MR elastography with liver T1 relaxation times obtained from T1 mapping and T2 relaxation times obtained from T2 mapping for detection and staging of liver fibrosis. MATERIALS AND
methods223 patients with known or suspected liver disease underwent MRI of the liver with T1 mapping (Look-Locker sequence) and 2D SE-EPI MR elastography (MRE) sequences. 139 of these patients also underwent T2 mapping with radial T2 TSE sequence. Two readers (R1 & R2) measured liver stiffness, T1 relaxation times and T2 relaxation times. T1 and T2 times were correlated with stiffness measurements. ROC analysis was used to compare the performance of both techniques in discriminating fibrosis stage in 23 patients who underwent liver biopsy.
resultsFor each reader there was significant moderate positive correlation between liver MRE and liver T1 mapping (r = 0.49 and 0.36). There was significant moderate positive correlation between liver T2 mapping and each of MRE and T1 mapping for one of the readers (r = 0.40 and 0.27). AUC for differentiating early (F0-F2) from advanced (F3-F4) fibrosis in biopsied patients was 0.975 (R1) and 0.925 (R2) for MRE, 0.671 (R1) and 0.642 (R2) for T1 mapping and 0.671 (R1) and 0.743 (R2) for T2 mapping. Inter-reader agreement was good for MRE (ICC = 0.84) substantial for T1 mapping (0.94) and T2 mapping (0.96).
conclusionsLiver T1 and T2 mapping showed moderate positive correlation with MR elastography. Accuracy of MRE is however superior to T1 and T2 mapping in the subset of patients who underwent liver biopsy. Accuracy of combination of MRE and T1 mapping/T2 mapping was not superior to MRE alone.
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