Evidence map›Paper›PMID 31875238›Full record

SynthesisSocial psychiatry and psychiatric epidemiology2020

Experiences of taking neuroleptic medication and impacts on symptoms, sense of self and agency: a systematic review and thematic synthesis of qualitative data.

Jemima Thompson, Jacki L Stansfeld, Ruth E Cooper, Nicola Morant, Nadia E Crellin, Joanna Moncrieff

Open access · hybridAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Social psychiatry and psychiatric epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jemima ThompsonResearch Department of Medical Education (RDME), Royal Free Hospital, University College London, London, UK.
Jacki L StansfeldResearch and Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, UK.
Ruth E CooperUnit for Social and Community Psychiatry, Newham Centre for Mental Health, Queen Mary University of London, London, UK.
Nicola MorantDivision of Psychiatry, University College London, London, UK.
Nadia E CrellinResearch and Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, UK.
Joanna MoncrieffResearch and Development Department, Goodmayes Hospital, North East London NHS Foundation Trust, Essex, UK. j.moncrieff@ucl.ac.uk.ORCID http://orcid.org/0000-0003-1214-6974
North East London NHS Foundation Trust · GBGoodmayes Hospital · GBQueen Mary University of London · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeuroleptic (antipsychotic) drugs reduce psychotic symptoms, but how they achieve these effects and how the drugs' effects are experienced by people who take them are less well understood. The present study describes a synthesis of qualitative data about mental and behavioural alterations associated with taking neuroleptics and how these interact with symptoms of psychosis and people's sense of self and agency.

methodsNine databases were searched to identify qualitative literature concerning experiences of taking neuroleptic medication. A thematic synthesis was conducted.

resultsNeuroleptics were commonly experienced as producing a distinctive state of lethargy, cognitive slowing, emotional blunting and reduced motivation, which impaired functioning but also had beneficial effects on symptoms of psychosis and some other symptoms (e.g. insomnia). For some people, symptom reduction helped restore a sense of normality and autonomy, but others experienced a loss of important aspects of their personality. Across studies, many people adopted a passive stance towards long-term medication, expressing a sense of resignation, endurance or loss of autonomy.

conclusionsNeuroleptic drugs modify cognition, emotions and motivation. These effects may be associated with reducing the intensity and impact of symptoms, but also affect people's sense of self and agency. Understanding how the effects of neuroleptics are experienced by those who take them is important in developing a more collaborative approach to drug treatment in psychosis and schizophrenia.

Indexed as

Self ConceptAdultAntipsychotic AgentsEmotionsFemaleHumansLethargyMaleMiddle AgedMotivationPersonal AutonomyPsychotic DisordersQualitative ResearchTreatment OutcomeYoung AdultAntipsychotic AgentsAntipsychoticsNeurolepticsPsychosisQualitative researchSchizophrenia

Identifiers

PMID31875238
OpenAlexW2997677254

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.