Evidence map›Paper›PMID 31875016›Full record

ArticleScientific reports2019

No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects.

Nunzia Passaro, Andrea Casagrande, Matteo Chiara, Bruno Fosso, Caterina Manzari, Anna Maria D'Erchia, Samuele Iesari, Francesco Pisani, Antonio Famulari, Patrizia Tulissi and 14 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
71.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 248 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 4 countries.

Nunzia PassaroItalian National Institute of Health, Dept. of Cell Biology and Neurosciences, Rome, 00161, Italy.
Andrea CasagrandeItalian National Institute of Health, Dept. of Oncology and Molecular Medicine, Rome, 00161, Italy.
Matteo ChiaraUniversity of Milan, Dept. of Biosciences, Milan, 20122, Italy.
Bruno FossoNational Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Bari, 70126, Italy.ORCID http://orcid.org/0000-0003-2324-086X
Caterina ManzariNational Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Bari, 70126, Italy.
Anna Maria D'ErchiaNational Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Bari, 70126, Italy.ORCID http://orcid.org/0000-0002-4627-0626
Samuele IesariUniversity of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, 67100, Italy.ORCID http://orcid.org/0000-0002-6918-945X
Francesco PisaniUniversity of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, 67100, Italy.
Antonio FamulariUniversity of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, 67100, Italy.
Patrizia TulissiASUIUD S. Maria della Misericordia, Nephrology Unit, Udine, 33100, Italy.
Stefania MastrosimoneULSS 2, Nephrology, Dialysis, Transplantation Unit, Treviso, 31100, Italy.
Maria Cristina MarescaULSS 2, Nephrology, Dialysis, Transplantation Unit, Treviso, 31100, Italy.
Giuseppe MercanteHumanitas University, Department of Biomedical Sciences, Milan, 20090, Italy.
Giuseppe SprianoHumanitas University, Department of Biomedical Sciences, Milan, 20090, Italy.
Giacomo CorradoRegina Elena National Cancer Institute, Dept. of Experimental Clinical Oncology, Gynecologic Oncology Unit, Rome, 00144, Italy.
Enrico VizzaRegina Elena National Cancer Institute, Dept. of Experimental Clinical Oncology, Gynecologic Oncology Unit, Rome, 00144, Italy.
Anna Rosa GarbugliaNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, Laboratory of Virology, Rome, 00149, Italy.
Maria Rosaria CapobianchiNational Institute for Infectious Diseases "L. Spallanzani" IRCCS, Laboratory of Virology, Rome, 00149, Italy.
Carla MottiniItalian National Institute of Health, Dept. of Cell Biology and Neurosciences, Rome, 00161, Italy.
Alessandra CenciItalian National Institute of Health, Dept. of Oncology and Molecular Medicine, Rome, 00161, Italy.
Marco TartagliaOspedale Pediatrico Bambino Gesù IRCCS, Genetics and Rare Diseases Research Division, Rome, 00165, Italy.
Alessandro Nanni CostaItalian National Institute of Health, National Transplant Center, Rome, 00162, Italy.
Graziano PesoleNational Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Bari, 70126, Italy.
Marco CrescenziItalian National Institute of Health, Core Facilities, Rome, 00161, Italy. marco.crescenzi@iss.it.
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies · ITUniversity of L'Aquila · ITAULSS 2 Marca Trevigiana · ITHumanitas University · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITAgostino Gemelli University Polyclinic · ITBambino Gesù Children's Hospital · ITNational Cancer Institute · MYNational Institute of Health · AMOspedale Santa Maria della Misericordia di Udine · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.

Indexed as

Immunocompromised HostComputational BiologyHumansImmunosuppression TherapyMetagenomeMetagenomicsMicrobiotaNeoplasmsOncogenic VirusesProbabilitySequence Analysis, RNAViruses

Identifiers

PMID31875016
PMCPMC6930283
OpenAlexW2997661360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.