ArticleScientific reports2019
Consequences of a short time exposure to a sublethal dose of Flupyradifurone (Sivanto) pesticide early in life on survival and immunity in the honeybee (Apis mellifera).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Meta-Analysis and Experimental Evidence Reveal No Impact of Nosema ceranae Infection on Honeybee Carbohydrate Consumption.Microbial ecology · 2025Pooled it
- Flupyradifurone impairs the processing of sound signals by the ascending interneurons AN1 and AN2 that convey auditory information to the cricket brain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Health management strategies of resilient honey bee stock throughout Southern California.Journal of economic entomology · 2026Article
- How Environmental and Ecological Stressors Reprogram Honey Bee Chemistry Through the Microbiome-Metabolome Axis.Insects · 2026Review
- Melatonin as a Potential Dietary Supplement to Counteract Glyphosate-Induced Decline in Honeybee Populations.Insects · 2026Article
- Clodronate Liposomes Untangle the Role of Hemocytes in <italic>Apis mellifera</italic> Response to Temperature Variation and Microbial Infection.Journal of innate immunity · 2026Article
- Synergistic effect of the next generation insecticide flupyradifurone with a fungal pathogen in the ant Lasius niger.Scientific reports · 2025Article
- Clodronate liposomes untangle the role of hemocytes inbioRxiv : the preprint server for biology · 2025Article
- Insect immunity in the Anthropocene.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Co-exposure to a honeybee pathogen and an insecticide: synergistic effects in a new solitary bee host but not inProceedings. Biological sciences · 2025Article
- The Role of Pathogens in Bumblebee Decline: A Review.Pathogens (Basel, Switzerland) · 2025Review
- Current Insights into Sublethal Effects of Pesticides on Insects.International journal of molecular sciences · 2024Review
- A novel insecticide impairs bumblebee memory and sucrose responsiveness across high and low nutrition.Royal Society open science · 2024Article
- Single and combined exposure to 'bee safe' pesticides alter behaviour and offspring production in a ground-nesting solitary bee (Proceedings. Biological sciences · 2024Article
- Effects of Plant-Based Supplement on Oxidative Stress of Honey Bees (Animals : an open access journal from MDPI · 2023Article
- Article
- Parasite and Pesticide Impacts on the Bumblebee (International journal of molecular sciences · 2023Article
- Article
- The Insecticide Imidacloprid DecreasesInsects · 2022Article
- Effect of amide protoporphyrin derivatives on immune response in Apis mellifera.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dramatic losses of pollinating insects have become of global concern, as they threaten not only key ecosystem services but also human food production. Recent research provided evidence that interactions between ecological stressors are drivers of declining pollinator health and responsible for observed population collapses. We used the honeybee Apis mellifera and conducted a series of experiments to test for long-term effects of a single short exposure to the agricultural pesticide flupyradifurone to a second environmental stressor later in life. To do this, we exposed individuals during their larval development or early adulthood to sublethal dosages of flupyradifurone (0.025 μg for larvae and 0.645 μg for imagos), either pure or as part of an agricultural formulation (Sivanto). We afterwards exposed bees to a second ecological stressor infecting individuals with 10,000 spores of the fungal gut parasite Nosema ceranae. We found that pesticide exposures significantly reduced survival of bees and altered the expression of several immune and detoxification genes. The ability of bees to respond to these latter effects differed significantly between colonies, offering opportunities to breed bees with elevated levels of pesticide tolerance in the future. We conclude that short episodes of sublethal pesticide exposures during development are sufficient to trigger effects later in life and could therefore contribute to the widespread declines in bee health.
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Registered trials
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