ArticleScientific reports2019
Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Brugada Syndrome Unmasked by Kratom Use in a Young Man.JACC. Case reports · 2026Article
- Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome.Cell discovery · 2025Review
- Exploring of cardiac autonomic activity with heart rate variability in long-term kratom (PeerJ · 2022Article
- Assessment of Cardiovascular Functioning Among Regular Kratom (Frontiers in pharmacology · 2021Article
- The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitragyna speciosa Korth (M. speciosa) has been widely used as a recreational product, however, there are growing concerns on the abuse potentials and toxicity of the plant. Several poisoning and fatal cases involving kratom and mitragynine have been reported but the underlying causes remain unclear. The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit underlying cardiac rapidly delayed rectifier potassium current (I
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Registered trials
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