Evidence map›Paper›PMID 31874915›Full record

ArticlemBio2019

Single-Cell Transcriptomics Reveal a Correlation between Genome Architecture and Gene Family Evolution in Ciliates.

Ying Yan, Xyrus X Maurer-Alcalá, Rob Knight, Sergei L Kosakovsky Pond, Laura A Katz

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 60 citations in OpenAlex.

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  17. Molecular phylogeny and taxonomy of fourZoological research · 2022
    Article
  18. Article
  19. Comparative Genome Analysis RevealsFrontiers in microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ying Yan *Smith College, Department of Biological Sciences, Northampton, Massachusetts, USA.ORCID 0000-0001-5194-9230
Xyrus X Maurer-Alcalá *Smith College, Department of Biological Sciences, Northampton, Massachusetts, USA.ORCID 0000-0002-7499-9369
Rob KnightUniversity of California San Diego, Department of Pediatrics, San Diego, California, USA.ORCID 0000-0002-0975-9019
Sergei L Kosakovsky PondTemple University, Institute for Genomics and Evolutionary Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4817-4029
Laura A KatzSmith College, Department of Biological Sciences, Northampton, Massachusetts, USA lkatz@smith.edu.ORCID 0000-0002-9138-4702
Smith College · USTemple University · USUniversity of California San Diego · US

Funding

Turning big data analysis infrastructure for HIV researchR01AI134384 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEKRUTENKO, ANTON, POND, SERGEI L KOSAKOVSKY · 2017 to 2021
$4.2M
HyPhy: Molecular Evolutionary AnalysesR01GM093939 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI MUSE, SPENCER V., POND, SERGEI L KOSAKOVSKY · 2010 to 2018
$2.5M
Assessing evolutionary patterns in uncultivable ciliates and their microbiomes by combining single-cell transcriptomics and single-cell genomicsR15HG010409 · NHGRI · SMITH COLLEGE · PI KATZ, LAURA ALINE · 2019 to 2019
$400k
Evolution of germline/soma distinctions across the eukaryotic tree of lifeR15GM113177 · NIGMS · SMITH COLLEGE · PI KATZ, LAURA ALINE · 2015 to 2015
$262k
NHGRI NIH HHS R15 HG010409NIAID NIH HHS R01 AI134384NIGMS NIH HHS R01 GM093939NIGMS NIH HHS R15 GM113177
6 · The paper itself

Abstract

Ciliates, a eukaryotic clade that is over 1 billion years old, are defined by division of genome function between transcriptionally inactive germline micronuclei and functional somatic macronuclei. To date, most analyses of gene family evolution have been limited to cultivable model lineages (e.g.,

Indexed as

Evolution, MolecularGene Expression ProfilingGenome, ProtozoanMultigene FamilyCiliophoraComputational BiologyGenetic VariationPhylogenySingle-Cell AnalysisCiliophoragene family evolutiongenetic code evolutionphylogenomicstranscriptomicsuncultivable microbes

Identifiers

PMID31874915
PMCPMC6935857
OpenAlexW2998458937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.