Evidence map›Paper›PMID 31874859›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2020

Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease.

Jennifer R Gatchel, Francisco Lopera, Daniel J Norton, Ana Baena, Edmarie Guzman-Velez, Justin S Sanchez, Federico d'Oleire Uquillas, Aaron Schultz, Patrizia Vannini, Arabiye Artola and 8 more

Abstract readLetter
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jennifer R GatchelPsychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Francisco LoperaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Daniel J NortonPsychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ana BaenaGrupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia.
Edmarie Guzman-VelezPsychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Justin S SanchezRadiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Federico d'Oleire UquillasNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Aaron SchultzNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Patrizia VanniniNeurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Arabiye ArtolaPsychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Rebecca E AmariglioNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Dorene M RentzNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pierre N TariotBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Eric M ReimanBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Keith A JohnsonRadiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Reisa A SperlingNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gad A MarshallNeurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Yakeel T QuirozPsychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA yquiroz@mgh.harvard.edu.ORCID 0000-0001-9714-8244

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8M
Memory network dysfunction as an early marker of preclinical Alzheimer's DiseaseDP5OD019833 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2014 to 2018
$2.3M
Depressive symptoms in the pathogenesis of preclinical Alzheimer's DiseaseK23AG058805 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GATCHEL, JENNIFER ROSE · 2018 to 2022
$992k
NIA NIH HHS K23 AG058805NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG054671NIH HHS DP5 OD019833
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseCognitive DysfunctionHumansMutationPresenilin-1Self ReportPresenilin-1PSEN1 protein, humanamyloidautosomal dominant Alzheimer’s Diseasepreclinicalpresenilin-1subjective cognitive decline (SCD)tau

Identifiers

PMID31874859
PMCPMC7397724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.