ArticleNeurobiology of aging2020
Medial temporal lobe white matter pathway variability is associated with individual differences in episodic memory in cognitively normal older adults.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Cognitive profiles among dementia-free older adults and their associations with neuroimaging markers.Brain imaging and behavior · 2025Article
- Tau PET Burden Is Associated With Hippocampal Microstructure and Episodic Memory in Amyloid Positive Older Adults.Hippocampus · 2025Article
- Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults.Neurobiology of aging · 2024Article
- Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.NeuroImage · 2024Article
- Intersubject similarity in neural representations underlies shared episodic memory content.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural and Functional Brain Connectivity Uniquely Contribute to Episodic Memory Performance in Older Adults.Frontiers in aging neuroscience · 2022Article
- Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.Frontiers in psychology · 2022Article
- Decreased myelin content of the fornix predicts poorer memory performance beyond vascular risk, hippocampal volume, and fractional anisotropy in nondemented older adults.Brain imaging and behavior · 2021Article
- Splenial white matter integrity is associated with memory impairments in posterior cortical atrophy.Brain communications · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate which measures, alone or in combination, were associated with individual differences in episodic memory performance. Using hierarchical linear regressions, we compared the ability of diffusion tensor imaging (DTI) metrics, CSF measures of amyloid and tau, and gray matter volumes to explain variability in memory performance in a cohort of cognitively normal older adults. Measures of DTI microstructure were significantly associated with variance in memory performance, even after accounting for the contribution of the CSF and magnetic resonance imaging gray matter volume measures. Significant associations were found between DTI measures of the hippocampal cingulum and fornix with individual differences in memory. No such relationships were found between memory performance and CSF markers or gray matter volumes. These findings suggest that DTI metrics may be useful in identifying changes associated with aging or age-related diseases.
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Registered trials
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