Evidence map›Paper›PMID 31874674›Full record

ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2019

[Advances in the Influence of EGFR Mutation on the PD-L1 Expression in Non-small Cell Lung Cancer].

Xiaoyu Zhi, Weiwei Li, Shaowei Wang, Jinliang Wang

Abstract read
In one paragraph

Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoyu ZhiDepartment of Medical Oncology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Weiwei LiDepartment of Medical Oncology, the Hospital of 81st Group Army PLA, Zhangjiakou 075000, China.
Shaowei WangKey Laboratory of Cancer Center, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Jinliang WangDepartment of Medical Oncology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researches on the inhibitors of programmed death-1 (PD-1) and programmed death-1 ligand (PD-L1) enjoy considerable breakthroughs in recent years, which has brought relative changes in the therapeutic model of non-small cell lung cancer (NSCLC) at an unexpected speed. However, it seems that PD-1/PD-L1 inhibitors are less effective in patients with epidermal growth factor receptor (EGFR) mutation than those without. Previous studies have shown that the expression rate of PD-L1 on tumor cells is correlated with the therapeutic effect of PD-1/PD-L1 inhibitors. Yet, there is no complete agreement on the effect of EGFR mutation on PD-L1 expression. In this review, relevant studies will be summarized with an expectation of making some contributions to basic researches and to the clinical treatment.

Indexed as

B7-H1 AntigenCarcinoma, Non-Small-Cell LungCell Line, TumorErbB ReceptorsFlow CytometryHumansLung NeoplasmsMutationB7-H1 AntigenCD274 protein, humanEGFR protein, humanErbB ReceptorsEGFR mutationLung neoplasmsPD-1/PD-L1 inhibitorsPD-L1

Identifiers

PMID31874674
PMCPMC6935036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.