Evidence map›Paper›PMID 31874428›Full record

ReviewBiomaterials2020

Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy.

Navid Rabiee, Mohammad Tavakkoli Yaraki, Soha Mokhtari Garakani, Shima Mokhtari Garakani, Sepideh Ahmadi, Aseman Lajevardi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri and 1 more

Abstract readReview
In one paragraph

Review in Biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Size-dependent modulation of intersystem crossing and singlet oxygen sensitization in porphyrin-silver cluster hybrid systems.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
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  7. Spectroscopic Analysis of the TiOInternational journal of molecular sciences · 2026
    Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Navid RabieeDepartment of Chemistry, Sharif University of Technology, Tehran, Iran. Electronic address: nrabiee94@gmail.com.
Mohammad Tavakkoli YarakiDepartment of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, 138634, Singapore.
Soha Mokhtari GarakaniDepartment of Biotechnology, Payame Noor University, P.O Box, 19395-3697, Alborz, Iran.
Shima Mokhtari GarakaniDepartment of Biotechnology, Payame Noor University, P.O Box, 19395-3697, Alborz, Iran.
Sepideh AhmadiStudent Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aseman LajevardiDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mojtaba BagherzadehDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Mohammad RabieeBiomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address: mrabiee@aut.ac.ir.
Lobat TayebiDepartment of Developmental Sciences, Marquette University, Milwaukee, WI, 53233, USA.
Mohammadreza TahririDepartment of Developmental Sciences, Marquette University, Milwaukee, WI, 53233, USA. Electronic address: mohammadreza.tahriri@marquette.edu.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, USA; Department of Dermatology, Harvard Medical School, Boston, USA; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa. Electronic address: hamblin@helix.mgh.harvard.edu.

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the "pigments of life". They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have been used to improve delivery characteristics. Porphyrins can be used in a composite designed material with properties that allow specific targeting, immune tolerance, extended tissue lifetime and improved hydrophilicity. Drug delivery, healing and repairing of damaged organs, and cancer theranostics are some of the medical uses of porphyrin-based nanocomposites covered in this review.

Indexed as

Metal NanoparticlesNanocompositesNanoparticlesPhotochemotherapyPorphyrinsAnimalsGoldMiceMice, NudeTheranostic NanomedicineTissue DistributionGoldPorphyrinsDrug deliveryNanocompositeNanoparticlePorphyrinTheranostics

Identifiers

PMID31874428
PMCPMC7008091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.