Evidence map›Paper›PMID 31873946›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Functionalization of Piperidine Derivatives for the Site-Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate.

Wenbin Liu, Tobias Babl, Alexander Röther, Oliver Reiser, Huw M L Davies

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. Organic letters · 2023
    Article
  7. Article
  8. Article
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  10. ACS catalysis · 2021
    Article
  11. Enantioselective Synthesis ofJournal of the American Chemical Society · 2021
    Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wenbin LiuDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322, USA.
Tobias BablDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322, USA.
Alexander RötherInstitute of Organic Chemistry, University of Regensburg, Universitätsstrasse 31, 93053, Regensburg, Germany.
Oliver ReiserInstitute of Organic Chemistry, University of Regensburg, Universitätsstrasse 31, 93053, Regensburg, Germany.ORCID http://orcid.org/0000-0003-1430-573X
Huw M L DaviesDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0001-6254-9398
Emory University · USUniversity of Regensburg · DE

Funding

N-Sulfonyltriazoles as Carbene PrecursorsR01GM099142 · NIGMS · EMORY UNIVERSITY · PI DAVIES, HUW M · 2011 to 2023
$4.1M
Elitenetzwerk Bayern (SYNCAT)National Science Foundation CHE 1531620National Science Foundation CHE 1626172National Science Foundation CHE-1700982NIGMS NIH HHS R01 GM099142NIH HHS GM099142
6 · The paper itself

Abstract

Rhodium-catalyzed C-H insertions and cyclopropanations of donor/acceptor carbenes have been used for the synthesis of positional analogues of methylphenidate. The site selectivity is controlled by the catalyst and the amine protecting group. C-H functionalization of N-Boc-piperidine using Rh

Indexed as

C−H functionalizationdiastereoselectivitypiperidinesregioselectivityrhodium

Identifiers

PMID31873946
PMCPMC7187323
OpenAlexW2997650997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.