ArticleMolecular biology reports2020
Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome.
Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- The effects of low-fat dairy products fortified with 1500 IU vitamin DJournal of health, population, and nutrition · 2023Trial
- Comparative study evaluating antihistamine versus leukotriene receptor antagonist as adjuvant therapy for rheumatoid arthritis.European journal of clinical pharmacology · 2021Trial
- Vascular Cell Adhesion Molecule 1 and E-Selectin as Potential Cardiovascular Risk Biomarkers in Psoriasis.International journal of molecular sciences · 2025Review
- Insulin resistance-related circulating predictive markers in the metabolic syndrome: a systematic review in the Iranian population.Journal of diabetes and metabolic disorders · 2024Review
- The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study.BMC endocrine disorders · 2024Article
- Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort.Molecular genetics & genomic medicine · 2023Article
- Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2023Article
- Elevation of preoperative serum hs-CRP is an independent risk factor for malnutrition in patients with gastric cancer.Frontiers in oncology · 2023Article
- Association between dietary patterns and body composition in normal-weight subjects with metabolic syndrome.Journal of diabetes and metabolic disorders · 2022Article
- Diagnostic Value of Color Doppler Flow Imaging Combined with Serum CRP, PCT, and IL-6 Levels for Neonatal Pneumonia.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Effect of C reactive protein on the sodium-calcium exchanger 1 in cardiomyocytes.Experimental and therapeutic medicine · 2021Article
- Genetic Scores ofInternational journal of environmental research and public health · 2021Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Metabolic syndrome (MetS) is associated with a pro-inflammatory state and endothelial dysfunction that places subjects with MetS at a higher risk of atherosclerosis. Inflammatory biomarkers are raised in patients at risk of developing cardiovascular diseases. In the current study, we aimed to examine the possible association between MetS and serum soluble adhesion molecules, hs-CRP, uric acid, and the genetic variations related to vascular endothelial growth factor (VEGF) gene. In this cross-sectional study, participants were enrolled from the Mashhad stroke and heart atherosclerotic disorders (MASHAD) study. The International Diabetes Federation criteria were used to define the MetS. Cell adhesion molecules (CAM) and serum hs-CRP were measured by ELISA and PEG-enhanced immunoturbidimetry method, respectively. We used a logistic regression analysis to determine independent associations of CAMs with the VEGF polymorphisms and MetS. Two hundred and 59 participants with and without MetS were enrolled. Participants with MetS and DM had a significantly higher serum E-selectin level (p < 0.05). Participants with a high serum E-selectin level had higher levels of hs-CRP, FBG, TG, uric acid, BMI and lower levels of serum HDL-C (p < 0.05). Interestingly, individuals with MetS with a genetic variant of the VEGF gene (rs6921438) had higher level of serum ICAM-1 (p = 0.04). There were significant associations between serum E-selectin concentrations and the presence of MetS, and its risk factors. Moreover, we demonstrated that MetS subjects with the rs6921438 genetic variant had a higher serum level of ICAM-1 (p < 0.05).
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