Evidence map›Paper›PMID 31873871›Full record

ArticleMolecular biology reports2020

The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis.

Ayat Kaeidi, Ali Sahamsizadeh, Mohammad Allahtavakoli, Iman Fatemi, Mohammadreza Rahmani, Elham Hakimizadeh, Jalal Hassanshahi

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  7. Review
  8. The contribution of the immune system to genitourinary fibrosis.Experimental biology and medicine (Maywood, N.J.) · 2022
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  10. Article
  11. Review
  12. Article
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  18. Article
  19. Potential Protective Role Exerted by Secoiridoids fromAntioxidants (Basel, Switzerland) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ayat KaeidiPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Ali SahamsizadehDepartment of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Khalije Fars Blvd., Pistachio Co. Street, P.O. Box:77175-835, 7719617996, Rafsanjan, Iran.
Mohammad AllahtavakoliDepartment of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Khalije Fars Blvd., Pistachio Co. Street, P.O. Box:77175-835, 7719617996, Rafsanjan, Iran.
Iman FatemiDepartment of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Khalije Fars Blvd., Pistachio Co. Street, P.O. Box:77175-835, 7719617996, Rafsanjan, Iran.
Mohammadreza RahmaniPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Elham HakimizadehPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Jalal HassanshahiDepartment of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Khalije Fars Blvd., Pistachio Co. Street, P.O. Box:77175-835, 7719617996, Rafsanjan, Iran. hasanshahij@rums.ac.ir.ORCID http://orcid.org/0000-0003-3754-8152
Rafsanjan University of Medical Sciences · IR

Funding

Rafsanjan University of Medical Sciences 97098
6 · The paper itself

Abstract

Unilateral ureteral obstruction (UUO) induces kidney injury. Oleuropein as a major compound of olive leaves modulates the inflammatory parameters and decreases oxidative stress. Accordingly, we evaluate the renoprotective effect of oleuropein against 3-day UUO rats. Forty rats were randomly divided into five groups (n = 8) including control, UUO and UUO + oleuropein groups (50, 100 and 200 mg/kg). UUO model was induced by left ureter ligation and continued for 3-day. Rats were treated synchronic daily for 3-day, then mean arterial pressure (MAP), renal perfusion pressure (RPP), renal blood flow (RBF), serum creatinine level, and also superoxide dismutase (SOD), glutathione peroxidase (GPx) activity levels and malondialdehyde (MDA) concentration (in the obstructed kidney) were measured. The western blotting method was applied to evaluate the Bax, Bcl-2, cleaved caspase-3 and TNF-α proteins expression level. The hematoxylin and eosin method was applied to evaluate the kidney tissue damage score (KTDS). UUO significantly increased RVR, KTDS, and MDA, cleaved caspase-3, Bax, serum creatinine and TNF-α protein levels (P < 0.05), and also significantly decreased RBF, SOD, and GPx and Bcl-2 protein expression levels (P < 0.001) in the obstructed kidney and oleuropein (200 mg/kg) significantly ameliorated the changes induced by UUO. Our findings showed that oleuropein has a renoprotective effect against 3-day UUO. The mechanisms underlying the observed effects may be related to its antioxidative stress, anti-apoptotic, and anti-inflammatory effects.

Indexed as

ApoptosisOxidative StressAnimalsbcl-2-Associated X ProteinCaspase 3CreatinineGlutathione PeroxidaseHemodynamicsInflammationIridoid GlucosidesIridoidsKidneyLipid PeroxidationMaleRats, WistarSuperoxide Dismutasebcl-2-Associated X ProteinCaspase 3CreatinineGlutathione PeroxidaseIridoid GlucosidesIridoidsoleuropeinSuperoxide DismutaseTumor Necrosis Factor-alphaApoptosisInflammationOleuropeinOxidative stressRatUnilateral ureteral obstruction

Identifiers

PMID31873871
OpenAlexW2996394143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.