ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2020
Functional and structural changes in aorta of mice divergently selected for basal metabolic rate.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Association of predicted basal metabolic rate and insulin resistance in a Chinese general population.BMC endocrine disorders · 2025Article
- Studying the Vascular Tone of Mouse Aortic Rings in a Standard Wire Myograph.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Metabolic Rate and Oxidative Stress as a Risk Factors in the Development of Colorectal Cancer.International journal of molecular sciences · 2024Article
- Causal Effects of Basal Metabolic Rate on Cardiovascular Disease: A Bidirectional Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Cell size, body size and Peto's paradox.BMC ecology and evolution · 2022Review
- Low basal metabolic rate as a risk factor for development of insulin resistance and type 2 diabetes.BMJ open diabetes research & care · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases (CVD) are one of the most common causes of mortality likely genetically linked to the variation in basal metabolic rate (BMR). A robust test of the significance of such association may be provided by artificial selection experiments on animals selected for diversification of BMR. Here we asked whether genetically determined differences in BMR correlate with anatomical shift in endothelium structure and if so, the relaxation and contraction responses of the aorta in mice from two lines of Swiss-Webster laboratory mice (Mus musculus) divergently selected for high or low BMR (HBMR and LBMR lines, respectively). Functional and structural study of aorta showed that a selection for divergent BMR resulted in the between-line difference in diastolic aortic capacity. The relaxation was stronger in aorta of the HBMR mice, which may stem from greater flexibility of aorta mediated by higher activity of Ca
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