Statins as Adjunctive Therapy Against Tuberculosis (TB): The Balance Between Statin-Induced Anti-TB Effect and Trained Immunity Suppression.

Zhidong Hu, Douglas B Lowrie, Xiao-Yong Fan

Abstract readLetterComment

In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

The advances in adjuvant therapy for tuberculosis with immunoregulatory compounds.Frontiers in microbiology · 2024
Review
Platelets mediate trained immunity against bone and joint infections in a mouse model.Bone & joint research · 2022
Article
Further insights into to the role of statins against active tuberculosis: systematic review and meta-analysis.Le infezioni in medicina · 2022
Review
The Prospect of Repurposing Immunomodulatory Drugs for Adjunctive Chemotherapy against Tuberculosis: A Critical Review.Antibiotics (Basel, Switzerland) · 2021
Review
Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?The Journal of infectious diseases · 2020
Article
Neutrophils in Tuberculosis-Associated Inflammation and Lung Pathology.Frontiers in immunology · 2020
Review

4 · The record

Corrections and comments

Commented on by
Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?2020
Comment on
Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.2020

5 · Who and what money

Authors and funding

3 authors.

Zhidong HuShanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.

Douglas B LowrieShanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.

Xiao-Yong FanShanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsTuberculosisAnimalsAntitubercular AgentsCombined Modality TherapyMiceAntitubercular AgentsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID31873749

DOI10.1093/infdis/jiz675

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.