ArticleScientific reports2019
Probabilistic Assessment of Nerve Regeneration with Diffusion MRI in Rat Models of Peripheral Nerve Trauma.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Diffusion MRI as A Biomarker for Monitoring Recovery After Surgical Repair of Traumatic Peripheral Nerve Injuries: A Longitudinal Case Series.Research square · 2026Article
- Modeling Postoperative Nerve Regeneration Using Diffusion MRI: A Preclinical Study of a Novel Mathematical Approach.Muscle & nerve · 2026Article
- Application of magnetic resonance diffusion tensor imaging for the treatment of hemifacial spasm.American journal of translational research · 2026Article
- Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model.PloS one · 2025Article
- Comparison of the Effects of Perineural and Intraperitoneal Ozone Therapy on Nerve Healing in an Experimental Sciatic Nerve Injury Model.Medicina (Kaunas, Lithuania) · 2024Article
- Model-based parcellation of diffusion MRI of injured spinal cord predicts hand use impairment and recovery in squirrel monkeys.Behavioural brain research · 2024Article
- Multiparametric Quantitative MRI of Peripheral Nerves in the Leg: A Reliability Study.Journal of magnetic resonance imaging : JMRI · 2024Article
- Updates in peripheral nerve surgery of the upper extremity: diagnosis and treatment options.Annals of translational medicine · 2023Review
- Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol.Scientific reports · 2023Article
- Correlation between diffusion tensor indices and fascicular morphometric parameters of peripheral nerve.Frontiers in physiology · 2023Article
- Evaluation of peripheral nerve acute crush injury in rabbits: comparison among diffusion kurtosis imaging, diffusion tensor imaging and electromyography.Magma (New York, N.Y.) · 2022Article
- Incorporating Blood Flow in Nerve Injury and Regeneration Assessment.Frontiers in surgery · 2022Review
- Noninvasive diffusion MRI to determine the severity of peripheral nerve injury.Magnetic resonance imaging · 2021Article
- Initial findings in traumatic peripheral nerve injury and repair with diffusion tensor imaging.Annals of clinical and translational neurology · 2021Article
- High-Field Diffusion Tensor Imaging of Median, Tibial, and Sural Nerves in Type 2 Diabetes With Morphometric Analysis.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Nerve regeneration after injury must occur in a timely fashion to restore function. Unfortunately, current methods (e.g., electrophysiology) provide limited information following trauma, resulting in delayed management and suboptimal outcomes. Herein, we evaluated the ability of diffusion MRI to monitor nerve regeneration after injury/repair. Sprague-Dawley rats were divided into three treatment groups (sham = 21, crush = 23, cut/repair = 19) and ex vivo diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) was performed 1-12 weeks post-surgery. Behavioral data showed a distinction between crush and cut/repair nerves at 4 weeks. This was consistent with DTI, which found that thresholds based on the ratio of radial and axial diffusivities (RD/AD = 0.40 ± 0.02) and fractional anisotropy (FA = 0.53 ± 0.01) differentiated crush from cut/repair injuries. By the 12
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