ArticleScientific reports2019
The local immune response during Echinococcus granulosus growth in a quantitative hepatic experimental model.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Effect of LY2109761 on TGF-β1/TGFβRI/Smad Pathway and Hepatic Fibrosis Cysts Formation in Rats Infected with Echinococcus granulosus: an In Vitro and In Vivo Study.Acta parasitologica · 2026Article
- A novel method for establishing a mouse model of hepatic echinococcosis: Ultrasound-guided percutaneous liver puncture modeling.PLoS neglected tropical diseases · 2026Article
- First report of Echinococcus granulosus genotype 1 in a wild boar (Sus scrofa) from China.Parasitology research · 2024Article
- Evaluation of the Local and Peripheral Immune Responses in Patients with Cystic Echinococcosis.Pathogens (Basel, Switzerland) · 2024Article
- Even a worm will turn: An atypical presentation of hydatid disease.Southern African journal of infectious diseases · 2024Article
- Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?Parasitology research · 2023Article
- Hepatic macrophages play critical roles in the establishment and growth of hydatid cysts in the liver during Echinococcus granulosus sensu stricto infection.PLoS neglected tropical diseases · 2023Article
- Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto.PLoS neglected tropical diseases · 2023Article
- Evaluation of the Local Immune Response to Hydatid Cysts in Sheep Liver.Veterinary sciences · 2023Article
- Article
- Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment.Infection and immunity · 2021Article
- lncRNA028466 regulates Th1/Th2 cytokine expression and associates with Echinococcus granulosus antigen P29 immunity.Parasites & vectors · 2021Article
- Severe Cystic Echinococcosis-Associated Immune Thrombocytopenic Purpura: A Case Report.Journal of hematology · 2021Article
- Article
- In-House Developed ELISA Indicates High Prevalence of Anti-Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local immune mechanisms responsible for the establishment and development of Echinococcus granulosus sensu stricto infection in the liver, have been little explored. We developed a suitable experimental model that mimics naturally infected livers using portal injection of protoscoleces. Opposite to Echinococcus multilocularis infection which is dose-dependent, fully mature hydatid cysts can be established in the liver whatever the injection dose; although most of the infection sites were seen at the establishment phase as inflammatory granulomas associated with fibrosis, they never matured into cysts. At the establishment phase, a strong immune response was composed of T and B cells, with T1-type, T2-type cells and cytokines and IL-10-secreting CD8
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