Evidence map›Paper›PMID 31873021›Full record

ArticleThe journal of physical chemistry. B2020

5-Carboxylcytosine and Cytosine Protonation Distinctly Alter the Stability and Dehybridization Dynamics of the DNA Duplex.

Brennan Ashwood, Paul J Sanstead, Qing Dai, Chuan He, Andrei Tokmakoff

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. ACS physical chemistry Au · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paul J Sanstead
Qing Dai

Funding

Labeling and sequencing of 5hmC and 5mC in DNA-RenewalR01HG006827 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2012 to 2025
$7.2M
The Dynamics of Molecular Recognition by Proteins from 2D IR Spectroscopy and MD SimulationsR01GM118774 · NIGMS · UNIVERSITY OF CHICAGO · PI TOKMAKOFF, ANDREI · 2016 to 2019
$1.6M
Investigation of 5-hmC, 5fC and 5-caC Modifications in Genome DNAK01HG006699 · NHGRI · UNIVERSITY OF CHICAGO · PI DAI, QING · 2012 to 2016
$702k
NHGRI NIH HHS K01 HG006699NHGRI NIH HHS R01 HG006827NIGMS NIH HHS R01 GM118774
6 · The paper itself

Abstract

Applications associated with nucleobase protonation events are grounded in their fundamental impact on DNA thermodynamics, structure, and hybridization dynamics. Of the canonical nucleobases, N3 protonation of cytosine (C) is the most widely utilized in both biology and nanotechnology. Naturally occurring C derivatives that shift the N3 p

Indexed as

ProtonsBase PairingCytosineDNAKineticsNucleic Acid HybridizationOligodeoxyribonucleotidesThermodynamics5-carboxylcytosineCytosineDNAOligodeoxyribonucleotidesProtons

Identifiers

PMID31873021
PMCPMC7109620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.