Evidence map›Paper›PMID 31872937›Full record

ReviewCellular microbiology2020

The zebrafish as a model for gastrointestinal tract-microbe interactions.

Erika M Flores, Anh T Nguyen, Max A Odem, George T Eisenhoffer, Anne Marie Krachler

Abstract readReview
In one paragraph

Review in Cellular microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Gut microbes · 2026
    Review
  3. Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Frontiers in microbiology · 2026
    Article
  15. Article
  16. Developmental regulation of intestinalbioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Animals : an open access journal from MDPI · 2025
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erika M FloresDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0003-3807-9044
Anh T NguyenDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0003-0488-7473
Max A OdemDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0002-3900-2973
George T EisenhofferM.D. Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas.ORCID 0000-0003-0188-6782
Anne Marie KrachlerDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0002-0936-0016

Funding

Mechanoregulation of EHEC virulenceR01AI132354 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Anne-Marie Krachler · 2018 to 2026
$3.5M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Regulation of Cell Turnover During Epithelial Tissue HomeostasisR01GM124043 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI EISENHOFFER, GEORGE THOMAS · 2018 to 2022
$2.0M
Role of mucin sulfation and sulfation-specific adhesins in AIEC colonizationR21AI151259 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KRACHLER, ANNE-MARIE · 2020 to 2021
$439k
NIAID NIH HHS R01 AI132354NIAID NIH HHS R21 AI151259NIAID NIH HHS T32 AI055449NIGMS NIH HHS R01 GM124043
6 · The paper itself

Abstract

The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it is a particularly useful model to address questions about the cellular microbiology of host-microbe interactions. Although its use as a model for systemic infections, as well as infections localised to the hindbrain and swimbladder having been thoroughly reviewed, studies focusing on host-microbe interactions in the zebrafish gastrointestinal tract have been neglected. Here, we summarise recent findings regarding the developmental and immune biology of the gastrointestinal tract, drawing parallels to mammalian systems. We discuss the use of adult and larval zebrafish as models for gastrointestinal infections, and more generally, for studies of host-microbe interactions in the gut.

Indexed as

ZebrafishAnimalsBacterial InfectionsDisease Models, AnimalGastrointestinal MicrobiomeGastrointestinal TractHost Microbial InteractionsInflammatory Bowel DiseasesLarvaMicrobial InteractionsProtozoan InfectionsDanio reriogastrointestinal tracthost-pathogen interactionsinfection modelmicrobiomemicrobiotazebrafish

Identifiers

PMID31872937
PMCPMC7015812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.