Evidence map›Paper›PMID 31872919›Full record

ArticleMagnetic resonance in medicine2020

7T bone perfusion imaging of the knee using arterial spin labeling MRI.

Xiufeng Li, Casey P Johnson, Jutta Ellermann

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xiufeng LiCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-0764-4613
Casey P JohnsonCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0001-9826-7296
Jutta EllermannCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Novel MRI Methods for Osteochondritis Dissecans (OCD) / Osteochondrosis (OC)R01AR070020 · NIAMS · UNIVERSITY OF MINNESOTA · PI CARLSON, CATHY S., ELLERMANN, JUTTA M · 2017 to 2021
$2.4M
Ultrahigh-Field MRI of Hip Joint Diseases Leading to Early OsteoarthritisK01AR070894 · NIAMS · UNIVERSITY OF MINNESOTA · PI JOHNSON, CASEY PETER · 2017 to 2021
$649k
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494NIAMS NIH HHS K01 AR070894NIAMS NIH HHS R01 AR070020NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061
6 · The paper itself

Abstract

purposeTo evaluate the feasibility of arterial spin labeling (ASL) imaging of epiphyseal bone marrow in the distal femoral condyle of the knee at 7T MRI.

methodsThe knees of 7 healthy volunteers were imaged with ASL using a 7T whole body MRI scanner and a 28-channel knee coil. ASL imaging used a flow-sensitive alternating inversion recovery method for labeling and a single-shot fast spin echo sequence for image readout. ASL imaging with a single oblique transverse slice was performed at 2 slice positions in the distal femoral condyle. Blood flow was measured in 2 regions of interest: the epiphyseal bone marrow and the overlying patellofemoral cartilage. To analyze perfusion SNR, 200 noise images were also acquired using the same ASL imaging protocol with RF pulses turned off.

resultsKnee bone marrow perfusion imaging was successfully performed with all volunteers. The overall mean of blood flow in the knee bone marrow was 32.90 ± 2.41 mL/100 g/min, and the blood flow was higher at the more distal slice position. We observed significant B

conclusionBone marrow perfusion imaging of the distal femoral condyle is feasible using ASL at 7T. Further technical development is needed to improve the ASL method to overcome existing challenges.

Indexed as

Magnetic Resonance ImagingPerfusion ImagingCerebrovascular CirculationHumansPerfusionReproducibility of ResultsSpin LabelsSpin Labels7Tarterial spin labelingASLblood flowknee bone marrowmagnetic resonance imagingMRIUHFultra-high field

Identifiers

PMID31872919
PMCPMC7473421
OpenAlexW2996825403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.