Evidence map›Paper›PMID 31872916›Full record

ArticleMagnetic resonance in medicine2020

d-glucose weighted chemical exchange saturation transfer (glucoCEST)-based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers and brain tumor patients.

Xiang Xu, Akansha Ashvani Sehgal, Nirbhay N Yadav, John Laterra, Lindsay Blair, Jaishri Blakeley, Anina Seidemo, Jennifer M Coughlin, Martin G Pomper, Linda Knutsson and 1 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 59 citations in OpenAlex.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Glucose exchange parameters in a subset of physiological conditions.Physical chemistry chemical physics : PCCP · 2023
    Article
  17. Review
  18. Advanced MR Techniques for Preoperative Glioma Characterization: Part 2.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Xiang XuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-8293-3776
Akansha Ashvani SehgalRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nirbhay N YadavRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
John LaterraDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Lindsay BlairDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jaishri BlakeleyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anina SeidemoDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.
Jennifer M CoughlinDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Linda KnutssonRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Peter C M van ZijlRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USKennedy Krieger Institute · USLund University · SE

Funding

Development and Translation of D-glucose as a Diagnostic Agent for MRI of CancerR01EB019934 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2015 to 2019
$5.7M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisR00EB026312 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI XU, XIANG · 2020 to 2022
$747k
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisK99EB026312 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, XIANG · 2018 to 2020
$242k
NIBIB NIH HHS K99 EB026312NIBIB NIH HHS R00 EB026312NIBIB NIH HHS R01 EB019934NIH HHS S10 OD021648
6 · The paper itself

Abstract

purposeDynamic glucose enhanced (DGE) MRI has shown potential for imaging glucose delivery and blood-brain barrier permeability at fields of 7T and higher. Here, we evaluated issues involved with translating d-glucose weighted chemical exchange saturation transfer (glucoCEST) experiments to the clinical field strength of 3T.

methodsExchange rates of the different hydroxyl proton pools and the field-dependent T

resultsSimulations showed that DGE signal decreases with B

conclusionMultislice glucoCEST-based DGE experiments can be performed at 3T with sufficient temporal resolution. However, the effects are small and prone to motion influence. Therefore, motion correction should be used when performing DGE experiments at clinical field strengths.

Indexed as

Brain NeoplasmsGliomaGlucoseHealthy VolunteersHumansMagnetic Resonance ImagingGlucoseCESTd-glucosefast exchangegliomaglucoCESTmotion correctionT2 relaxationZ-spectrum

Identifiers

PMID31872916
PMCPMC7083699
OpenAlexW2998353929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.