ArticleeLife2019
Spinal signalling of C-fiber mediated pleasant touch in humans.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Trial
- Modulation of pain by affective touch: effects of childhood trauma, depression, chronic pain, and spinal segment.The Journal of physiology · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition.Molecular brain · 2025Article
- CT-Optimal Stimulation Modulates Somatosensory Processing.Psychophysiology · 2025Article
- Linking heartbeats with the cortical network dynamics involved in self-social touch distinction.Communications biology · 2025Article
- The human spinothalamic tract: lessons from cordotomy.Brain communications · 2025Review
- Hedonic and autonomic responses in promoting affective touch.Scientific reports · 2023Article
- Article
- Article
- Atypical Response to Affective Touch in Children with Autism: Multi-Parametric Exploration of the Autonomic System.Journal of clinical medicine · 2022Article
- A wearable soft robot that can alleviate the pain and fear of the wearer.Scientific reports · 2022Article
- Gentle stroking elicits somatosensory ERP that differentiates between hairy and glabrous skin.Social cognitive and affective neuroscience · 2022Article
- Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line.Molecular pain · 2022Article
- Neural basis of affective touch and pain: A novel model suggests possible targets for pain amelioration.Journal of neuropsychology · 2022Review
- Hearing, touching, and multisensory integration during mate choice.Frontiers in neural circuits · 2022Review
- Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line.Scientific reports · 2021Article
- Physical contact in parent-infant relationship and its effect on fostering a feeling of safety.iScience · 2021Review
- The Anticipation and Perception of Affective Touch in Women with and Recovered from Anorexia Nervosa.Neuroscience · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.