Evidence map›Paper›PMID 31872574›Full record

ArticleStem cells translational medicine2020

Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration.

Federica Casiraghi, Norberto Perico, Eliana Gotti, Marta Todeschini, Marilena Mister, Monica Cortinovis, Valentina Portalupi, Anna Rita Plati, Flavio Gaspari, Alessandro Villa and 3 more

Abstract readCase Reports
In one paragraph

Article in Stem cells translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Cellular therapies in organ transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Review
  15. Review
  16. Article
  17. The emergence of regenerative medicine in organ transplantation: 1st European Cell Therapy and Organ Regeneration Section meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Federica CasiraghiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Norberto PericoIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Eliana GottiUnit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Marta TodeschiniIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Marilena MisterIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Monica CortinovisIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Valentina PortalupiUnit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Anna Rita PlatiUnit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Flavio GaspariIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Alessandro VillaIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Martino IntronaG. Lanzani Laboratory of Cell Therapy, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Elena LonghiLaboratory of Transplant Immunology, UOC Coordinamento Trapianti IRCCS Fondazione Ca' Granda - Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Giuseppe RemuzziIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.ORCID 0000-0002-6194-3446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we report the case of successful immune tolerance induction in a living-donor kidney transplant recipient remotely treated with autologous bone marrow-derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long-term kidney allograft function.

Indexed as

Kidney TransplantationMesenchymal Stem Cell TransplantationTransplantation ToleranceAdultHumansMaleMesenchymal Stem CellsTransplantation, Homologousimmunoregulationimmunosuppression withdrawalkidney transplantationmesenchymal stromal cellstolerance

Identifiers

PMID31872574
PMCPMC7103624

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.