ArticleThe Journal of comparative neurology2020
Spatial models of cell distribution in human lumbar dorsal root ganglia.
Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity.bioRxiv : the preprint server for biology · 2025Article
- Article
- The effects of neuron morphology and spatial distribution on the selectivity of dorsal root ganglion stimulation.Journal of neural engineering · 2024Article
- Computational modeling of dorsal root ganglion stimulation using an Injectrode.Journal of neural engineering · 2024Article
- Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model.International journal of molecular sciences · 2024Article
- Closed-loop sacral neuromodulation for bladder function using dorsal root ganglia sensory feedback in an anesthetized feline model.Medical & biological engineering & computing · 2022Article
- Dorsal Root Ganglion Volumetry by MR Gangliography.AJNR. American journal of neuroradiology · 2022Article
- Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action.The journal of pain · 2022Review
- Dorsal root ganglion stimulation produces differential effects on action potential propagation across a population of biophysically distinct C-neurons.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Stimulation of the dorsal root ganglion using an InjectrodeJournal of neural engineering · 2021Article
- High-density neural recordings from feline sacral dorsal root ganglia with thin-film array.Journal of neural engineering · 2021Article
- Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability.Annals of biomedical engineering · 2021Article
- Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation.Journal of pain research · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dorsal root ganglia (DRG), which contain the somata of primary sensory neurons, have increasingly been considered as novel targets for clinical neural interfaces, both for neuroprosthetic and pain applications. Effective use of either neural recording or stimulation technologies requires an appropriate spatial position relative to the target neural element, whether axon or cell body. However, the internal three-dimensional spatial organization of human DRG neural fibers and somata has not been quantitatively described. In this study, we analyzed 202 cross-sectional images across the length of 31 human L4 and L5 DRG from 10 donors. We used a custom semi-automated graphical user interface to identify the locations of neural elements in the images and normalize the output to a consistent spatial reference for direct comparison by spinal level. By applying a recursive partitioning algorithm, we found that the highest density of cell bodies at both spinal levels could be found in the inner 85% of DRG length, the outer-most 25-30% radially, and the dorsal-most 69-76%. While axonal density was fairly homogeneous across the DRG length, there was a distinct low density region in the outer 7-11% radially. These findings are consistent with previous qualitative reports of neural distribution in DRG. The quantitative measurements we provide will enable improved targeting of future neural interface technologies and DRG-focused pharmaceutical therapies, and provide a rigorous anatomical description of the bridge between the central and peripheral nervous systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.