ArticleTranslational stroke research2020
Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling.
Abstract read
In one paragraph
Article in Translational stroke research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Natural herbal extract roles and mechanisms in treating cerebral ischemia: A systematic review.Frontiers in pharmacology · 2024Pooled it
- Glycyrrhizic Acid Relieves Fatigue Induced by Acute and Chronic Exercise in Mice via Inhibition of the NF-κB/NLRP3 Signaling Pathway.Brain and behavior · 2026Article
- Extracellular vesicles: Revolutionizing targeted therapy for ischemic stroke.Acta pharmaceutica Sinica. B · 2026Review
- Proteoglycan 4 attenuates ischemic post-stroke hemorrhagic transformation and blood-brain barrier disruption.IBRO neuroscience reports · 2025Article
- HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation.Translational stroke research · 2025Review
- Safflower Yellow Pigment Alleviates Cerebral Ischemia-Reperfusion Injury via Protein Nitration and Oxidative Modulation.Brain and behavior · 2025Article
- MicroRNAs Associated with Parenchymal Hematoma After Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rats.Biomedicines · 2025Article
- Article
- Mechanisms of QiShenYiQi in Inhibiting Blood-Brain Barrier Damage Following Stroke: A Network Pharmacology and Experimental Study.Combinatorial chemistry & high throughput screening · 2025Article
- Neuroprotective Potential of Glycyrrhizic Acid in Ischemic Stroke: Mechanisms and Therapeutic Prospects.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Eicosapentaenoic Acid Improves Endothelial Nitric Oxide Bioavailability Via Changes in Protein Expression During Inflammation.Journal of the American Heart Association · 2024Article
- Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury.Journal of neuroinflammation · 2024Article
- The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion.Frontiers in immunology · 2024Review
- Enriched environment may improve secondary brain injury after traumatic brain injury by regulating the TLR2/NF-κB signaling pathway.Journal of central nervous system disease · 2024Article
- Elevated Serum HMGB1 Levels and Their Association with Recurrence of Acute Ischaemic Stroke.Journal of inflammation research · 2024Article
- Associations of diabetes status and glucose measures with outcomes after endovascular therapy in patients with acute ischemic stroke: an analysis of the nationwide TREAT-AIS registry.Frontiers in neurology · 2024Article
- Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke.Cell & bioscience · 2023Review
- QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.iScience · 2023Article
- Glycyrrhizic Acid Inhibits High-Mobility Group Box-1 and Homocysteine-Induced Vascular Dysfunction.Nutrients · 2023Article
- HMGB1, angel or devil, in ischemic stroke.Brain and behavior · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Hansen ChenSchool of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China.
Binghe GuanSchool of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China.
Bin WangSchool of Medical Technology, Xuzhou Medical University, Xuzhou, 221002, China.
Haiwei PuSchool of Medical Technology, Xuzhou Medical University, Xuzhou, 221002, China.
Xiaoyu BaiDepartment of Chemistry, Morningside Laboratory for Chemical Biology, The University of Hong Kong, Hong Kong, SAR, China.
Xi ChenSchool of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China.
Jihong LiuDepartment of Neurology, Huizhou First Hospital, Huizhou, Guangdong, China.
Caiming LiDepartment of Neurology, Huizhou First Hospital, Huizhou, Guangdong, China.
Jinhua QiuDepartment of Neurology, Huizhou First Hospital, Huizhou, Guangdong, China.
Dan YangDepartment of Chemistry, Morningside Laboratory for Chemical Biology, The University of Hong Kong, Hong Kong, SAR, China.
Kejian LiuDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of New Mexico, Albuquerque, NM, 87131, USA.
Qi WangInstitution of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China.
Suhua QiSchool of Medical Technology, Xuzhou Medical University, Xuzhou, 221002, China. suhuaqi@xzhmu.edu.cn.
Jiangang ShenSchool of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China. shenjg@hkucc.hku.hk.ORCID http://orcid.org/0000-0003-4772-5300
Chinese University of Hong Kong · HKHuizhou Central People's Hospital · CNXuzhou Medical College · CNGuangzhou University of Chinese Medicine · CNUniversity of Hong Kong · HKUniversity of New Mexico · US
Funding
Areas of Excellence Scheme, Hong Kong AoE/P-705/16Health and Medical Research Fund, Hong Kong SAR 13142901Hong Kong General Research Fund 17102915Hong Kong General Research Fund 17118711National Natural Science Foundation of China 81671164Shenzhen Basic Research Plan Project SIRI/04/04/2015/06
Abstract
Peroxynitrite (ONOO
Indexed as
AnimalsBrainBrain IschemiaDisease Models, AnimalGlycyrrhizic AcidHemorrhageHMGB1 ProteinIschemic StrokePeroxynitrous AcidRats, Sprague-DawleyThrombosisGlycyrrhizic AcidHMGB1 ProteinPeroxynitrous AcidGlycyrrhizinHemorrhagic transformation (HT)High mobility group box protein 1 (HMGB1)Peroxynitrite (ONOO−)Tissue plasminogen activator (t-PA)
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.