ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of anxiety and depression on hematologic malignancy outcomes: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Mental Health and Survival in Medicare Beneficiaries With Lung and Head and Neck Cancer.Psycho-oncology · 2026Article
- Prevalence of Depressive Symptoms in Patients Undergoing Aseptic Revision Total Hip Arthroplasty Differs Based on Mode of Failure.Arthroplasty today · 2025Article
- Prevalence of Depressive Symptoms in Aseptic Revision Total Knee Arthroplasty Based on the Mode of Failure.Arthroplasty today · 2024Article
- Health-related quality of life in adults with hematological cancer: a 2023 cross-sectional survey from Qatar.Frontiers in oncology · 2024Article
- Predictors of health-related quality of life of the patients treated for MM: the first study in the Palestinian healthcare system.Annals of hematology · 2023Article
- Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China.BMJ open · 2023Article
- Observational
- Increased Prevalence of Depressive Symptoms in Patients Undergoing Revision for Periprosthetic Joint Infection.Arthroplasty today · 2022Article
- Health-related Quality of Life in Hormone Receptor-Positive Early Breast Cancer: Analyses From the Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey.Journal of patient experience · 2022Article
- Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy.Frontiers in psychology · 2022Article
- Impact of depression on adherence to lenalidomide plus low-dose dexamethasone in patients with relapsed or refractory myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
purposeTo examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).
methodsWe performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified, and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans RAND 12 mental component summary (MCS) scores were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.
resultsOf 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR = 1.01, 95% CI 0.79-1.29) or cancer-specific mortality (HR = 0.94, 95% CI 0.69-1.28). MM patients scoring in the second MCS tertile (vs the highest tertile) had a modestly increased risk of all-cause (HR = 1.19, 95% CI 0.91-1.55) and cancer-specific mortality (HR = 1.17, 95% CI 0.86-1.60), but these estimates were not statistically significant.
conclusionPre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserve clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population.
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