Evidence map›Paper›PMID 31872282›Full record

ArticlePediatric cardiology2020

Novel Urinary Biomarkers for Acute Kidney Injury and Prediction of Clinical Outcomes After Pediatric Cardiac Surgery.

Fumiya Yoneyama, Toru Okamura, Kiyohiro Takigiku, Satoshi Yasukouchi

Abstract read
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In one paragraph

Article in Pediatric cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  11. The Use of Renal Biomarkers in Pediatric Cardiac Patients With Acute Kidney Injury.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fumiya YoneyamaDepartment of Cardiovascular Surgery, Pediatrics Cardiology, Nagano Children's Hospital, Toyoshina, Azumino, Nagano, 3100, Japan. fumiya.y@hotmail.co.jp.ORCID http://orcid.org/0000-0001-6862-0087
Toru OkamuraDepartment of Cardiovascular Surgery, Pediatrics Cardiology, Nagano Children's Hospital, Toyoshina, Azumino, Nagano, 3100, Japan.
Kiyohiro TakigikuDepartment of Cardiovascular Surgery, Pediatrics Cardiology, Nagano Children's Hospital, Toyoshina, Azumino, Nagano, 3100, Japan.
Satoshi YasukouchiDepartment of Cardiovascular Surgery, Pediatrics Cardiology, Nagano Children's Hospital, Toyoshina, Azumino, Nagano, 3100, Japan.
Nagano Children's Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a serious complication of pediatric cardiac surgery, with high morbidity and mortality. We aimed to evaluate the perioperative risk factors for AKI, and the validity of novel diagnostic urinary biomarkers after pediatric cardiac surgery. We analyzed 103 consecutive pediatric patients (≤ 18 years old), who underwent cardiac surgery. AKI was defined by ≥ 50% increase in serum creatinine levels from baseline. Urinary liver-type fatty acid binding protein (L-FABP) and neutrophil gelatinase-associated lipocalin (NGAL) were measured postoperatively at the intensive care unit (ICU) admission, subsequently at 4, 12, and 24 h. Areas under the receiver-operating characteristic curves (AUC) were calculated at each assessment time. AKI had developed in 47 patients (45.6%) by the second postoperative day. Univentricular status, aortic cross-clamping time, and intraoperative fluid balance were independently associated with AKI (p = 0.02, 0.01 and 0.01, respectively). Urinary L-FABP and NGAL were significantly higher in the AKI group at each point (p < 0.05). The predictive abilities of both biomarkers (AUC = 0.78-0.90) at ICU admission and 4 h after were especially high. The patients with L-FABP greater than the cutoff value at ICU admission and 4 h after ICU admission had significantly longer intubation and hospitalization periods (p < 0.05). Those with elevated NGAL levels at admission, and 4 h and 24 h after ICU admission, had significantly longer intubation, ICU stay, and hospitalization (p < 0.05). L-FABP and NGAL can be useful biomarkers for detecting early AKI after pediatric cardiac surgery and predicting adverse clinical outcomes.

Indexed as

Acute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresChildCreatinineFatty Acid-Binding ProteinsFemaleHumansLipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodROC CurveBiomarkersCreatinineFABP1 protein, humanFatty Acid-Binding ProteinsLCN2 protein, humanLipocalin-2LipocalinsAcute kidney injuryL-FABPNGALPediatric cardiac surgeryUrinary biomarkers

Identifiers

PMID31872282
OpenAlexW2995835089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.