Evidence map›Paper›PMID 31872280›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

The management impact of

Meghana Kulkarni, Simon Hughes, Andrew Mallia, Victoria Gibson, Jennifer Young, Ajay Aggarwal, Stephen Morris, Ben Challacombe, Rick Popert, Christian Brown and 4 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. EfficientInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Polish journal of radiology · 2023
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Cold Kit Labeling: The Future ofFrontiers in medicine · 2022
    Review
  13. Diagnostics (Basel, Switzerland) · 2021
    Article
  14. Review
  15. Review
  16. Clinical Utility ofFrontiers in oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Meghana KulkarniUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK. Mkulkarni1@gmail.com.ORCID 0000-0002-4222-7647
Simon HughesDepartment of Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Andrew MalliaCancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Victoria GibsonDepartment of Nuclear Medicine, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Jennifer YoungDepartment of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Ajay AggarwalDepartment of Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Stephen MorrisDepartment of Oncology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.
Ben ChallacombeUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK.
Rick PopertUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK.
Christian BrownUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK.
Paul CathcartUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK.
Prokar DasguptaUrology Centre, Guy's & St Thomas' NHS Trust, London, SE1 7EH, UK.
Victoria S WarbeyCancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Gary J R CookCancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Guy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBSt Thomas' Hospital · GB

Funding

Cancer Research UK 16463Cancer Research UK A16463Medical Research Council MC_PC_16048Wellcome Trust 203148
6 · The paper itself

Abstract

purposeTo determine the impact on clinical management of patients with high-risk (HR) prostate cancer at diagnosis and patients with biochemical recurrence (BCR) using a new kit form of

methodsOne hundred eighteen consecutive patients (50 HR, 68 BCR) had management plans documented at a multidisciplinary meeting before

resultsHR group: 12/50 (24%) patients had management changed (9 inter-modality, 3 intra-modality). Patients with PSA < 20 μg/L had more frequent management changes (9/26, 34.6%) compared with PSA > 20 μg/L (3/24, 12.5%). Gleason scores > 8 were associated with detection of more nodal (4/16, 25% vs 5/31, 16.1%) and bone (2/16, 12.5% vs 2/31, 6.5%) metastases. BCR group: Clinical management changed in 23/68 (34%) patients (17 inter-modality, 6 intra-modality). Forty out of 68 (59%) scans were positive. Positivity rate increased with PSA level (PSA < 0.5 μg/L, 0%; PSA 0.5-1.0 μg/L, 35%; PSA 1.0-5.0 μg/L, 69%; PSA 5.0-10.0 μg/L, 91%), PSAdt of < 6 months (56% vs 45.7%) and Gleason score > 8 (78.9% vs 51.2%).

conclusions

Indexed as

GalliumProstatic NeoplasmsEdetic AcidGallium RadioisotopesHumansMalePositron Emission Tomography Computed TomographyProstate-Specific AntigenEdetic AcidGalliumGallium RadioisotopesProstate-Specific Antigen68Ga-THP-PSMAManagement impactProstate cancerProstate-specific membrane antigenPSMA-PET-CT

Identifiers

PMID31872280
PMCPMC7005085
OpenAlexW2990480584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.