ArticleEuropean heart journal2020
Risk of hypertension into adulthood in persons born prematurely: a national cohort study.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Research focus and emerging trends of the gut microbiome and infant: a bibliometric analysis from 2004 to 2024.Frontiers in microbiology · 2024Pooled it
- Reporting and risk of bias of prediction models based on machine learning methods in preterm birth: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2023Pooled it
- Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- The association between late preterm birth and cardiometabolic conditions across the life course: A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- Pooled it
- General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial.BMC medicine · 2024Trial
- The relationship between plasminogen activator inhibitor-1 levels and blood pressure in adolescents with a history of prematurity and/or low birth weight.Pediatric nephrology (Berlin, Germany) · 2026Article
- Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence.Pediatric research · 2026Article
- Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm.Pediatric research · 2026Article
- Structural and Functional Abnormalities in the Preterm Heart: From Development to Adulthood.Journal of the American Heart Association · 2026Review
- Prospective observational study of brain magnetic resonance imaging in adolescents with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Renal consequences of prematurity and utility of serum uromodulin as a marker of kidney growth- a cross sectional single centre study.BMC nephrology · 2026Article
- Cardiometabolic characteristics of school-aged children born preterm with very low birth weight.Pediatric research · 2026Observational
- Cardiac autonomic function in adults born preterm with very low birth weight in mid-adulthood-A two-country birth cohort study.Physiological reports · 2025Article
- Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.Pediatric research · 2025Article
- Prematurity, Neonatal Complications, and the Development of Childhood Hypertension.JAMA network open · 2025Article
- Psychological and Physical Health of a Preterm Birth Cohort at Age 35 Years.JAMA network open · 2025Article
- Secondary Hypertension in Children-Identifying and Investigating at Risk Children.Current hypertension reports · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
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3 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsPreterm birth has been associated with elevated blood pressure early in life; however, hypertension risks from childhood into adulthood remain unclear. We conducted a large population-based study to examine gestational age at birth in relation to hypertension risks from childhood into adulthood. METHODS AND
resultsA national cohort study was conducted of all 4 193 069 singleton live births in Sweden during 1973-2014, who were followed up for hypertension identified from nationwide inpatient and outpatient (specialty and primary care) diagnoses from any health care encounters through 2015 (maximum age 43 years; median 22.5). Cox regression was used to examine gestational age at birth in relation to hypertension risk while adjusting for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. In 86.8 million person-years of follow-up, 62 424 (1.5%) persons were identified with hypertension (median age 29.8 years at diagnosis). Adjusted hazard ratios for new-onset hypertension at ages 18-29 years associated with preterm (<37 weeks) and extremely preterm (22-27 weeks) birth were 1.28 [95% confidence interval (CI), 1.21-1.36] and 2.45 (1.82-3.31), respectively, and at ages 30-43 years were 1.25 (1.18-1.31) and 1.68 (1.12-2.53), respectively, compared with full-term birth (39-41 weeks). These associations affected males and females similarly and appeared substantially related to shared genetic or environmental factors in families.
conclusionsIn this large national cohort, preterm birth was associated with increased risk of hypertension into early adulthood. Persons born prematurely may need early preventive evaluation and long-term monitoring for the development of hypertension.
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