ArticleCommunications biology2019
Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.
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Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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32citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma.Nature communications · 2025Pooled it
- Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.Scientific reports · 2025Pooled it
- GWAS Meta-analysis Identifies Novel Associated Loci and Points to Causal Tissues in Central Serous Chorioretinopathy.medRxiv : the preprint server for health sciences · 2026Article
- Associations ofOphthalmology science · 2026Article
- Article
- Treatment of central serous chorioretinopathy: new options for an old disease.Eye (London, England) · 2025Review
- Targeting the Tie-2 Receptor With Faricimab in Central Serous Chorioretinopathy: A Case Series Motivated by a Genetic Finding.American journal of ophthalmology · 2025Article
- Familial Occurrence of a Severe Phenotype of Central Serous Chorioretinopathy in Two Brothers.Cureus · 2024Article
- Vortex Veins in Eyes With Pachychoroid Spectrum Disorders Evaluated by the Adjusted Reverse 3-Dimensional Projection Model.Ophthalmology science · 2023Article
- Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes.Nature communications · 2023Article
- Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.Investigative ophthalmology & visual science · 2023Article
- Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration.JAMA ophthalmology · 2023Article
- Multi-Polymorphism Analysis Reveals Joint Effects in Males With Chronic Central Serous Chorioretinopathy.Investigative ophthalmology & visual science · 2023Article
- OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2023Review
- Relationship Between Scleral Thickness and Choroidal Structure in Central Serous Chorioretinopathy.Investigative ophthalmology & visual science · 2023Article
- Incidence of central serous chorioretinopathy (2011-2018): a nationwide population-based cohort study of Japan.The British journal of ophthalmology · 2022Article
- Natural Course of Pachychoroid Pigment Epitheliopathy.Ophthalmology science · 2022Article
- An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy.Investigative ophthalmology & visual science · 2022Article
- Distinct characteristics of central serous chorioretinopathy according to gender.Scientific reports · 2022Article
- Effectiveness of Reduced-fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: A Propensity Score Analysis.Ophthalmology science · 2022Article
Corrections and comments
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Authors and funding
34 authors at 12 institutions in 3 countries.
Yoshikatsu Hosoda1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Masahiro Miyake1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Rosa L SchellevisDepartment of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Camiel J F Boon4Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Carel B HoyngDepartment of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Akiko Miki5Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
Akira Meguro6Department of Ophthalmology and Visual Sciences, Yokohama City University School of Medicine, Yokohama, Japan.
Yoichi Sakurada7Department of Ophthalmology, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
Seigo Yoneyama7Department of Ophthalmology, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
Yukari Takasago8Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
Masayuki Hata1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yuki Muraoka1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hideo Nakanishi1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akio Oishi1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-0977-9458
Sotaro Ooto1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hiroshi Tamura1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-7740-2732
Akihito Uji1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Manabu Miyata1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0002-7574-1749
Ayako Takahashi1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Naoko Ueda-Arakawa1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Atsushi Tajima9Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa Japan.ORCID 0000-0001-6808-5491
Takehiro Sato9Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa Japan.ORCID 0000-0001-9866-0346
Nobuhisa Mizuki6Department of Ophthalmology and Visual Sciences, Yokohama City University School of Medicine, Yokohama, Japan.
Chieko Shiragami8Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.ORCID 0000-0002-4249-1229
Tomohiro Iida10Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan.
Chiea Chuen Khor11Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.ORCID 0000-0002-1128-4729
Tien Yin Wong11Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Ryo Yamada2Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shigeru Honda5Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
Eiko K de JongDepartment of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0001-6520-0407
Anneke I den HollanderDepartment of Ophthalmology, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0003-0634-5408
Fumihiko Matsuda2Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kenji Yamashiro *1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID 0000-0001-9354-8558
Akitaka Tsujikawa *1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kyoto University · JPRadboud University Nijmegen · NLKagawa University · JPKanazawa University · JPUniversity of Yamanashi · JPYokohama City University · JPKobe University · JPLeiden University Medical Center · NLNational University of Singapore · SGOsaka City University · JPSingapore National Eye Center · SGTokyo Women's Medical University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci:
Indexed as
Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyAllelesCase-Control StudiesCentral Serous ChorioretinopathyComputational BiologyDatabases, GeneticEuropeFemaleGene ExpressionHumansMaleOdds RatioQuantitative Trait LociGenome-wide association studiesRetinal diseases
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