Evidence map›Paper›PMID 31871935›Full record

SynthesisBioMed research international2019

Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects.

Guangyuan Chen, Cong Hu, Yuxuan Song, Haifei Zhang, Song Li, Penghui Lai, Yiling Zhang, Peng Huang

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guangyuan Chen *The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-0328-6062
Cong Hu *The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0001-6503-7750
Yuxuan Song *Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China.ORCID https://orcid.org/0000-0001-8326-0948
Haifei ZhangThe Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0001-9622-0259
Song LiThe Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-1664-6290
Penghui LaiThe Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-7256-3123
Yiling ZhangThe Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi 330006, China.ORCID https://orcid.org/0000-0002-2778-332X
Peng HuangCenter for Evidence-Based Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.ORCID https://orcid.org/0000-0001-8413-3377
Nanchang University · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial. Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis.

methodsWe searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards. The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies' quality evaluation.

results17 studies were included in total, with 5,061 patients and 6,346 control cases. A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs. TT:

conclusionThere is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians. And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAsian PeopleCarcinoma, Renal CellDatabases, FactualHumansInterleukin-4Kidney NeoplasmsNeoplasmsRiskSmokingInterleukin-4

Identifiers

PMID31871935
PMCPMC6913344
OpenAlexW2990457392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.