Evidence map›Paper›PMID 31871882›Full record

ArticleJournal of bone oncology2019

Mouse model recapitulates the phenotypic heterogeneity of human adult T-cell leukemia/lymphoma in bone.

Nicole A Kohart, Said M Elshafae, Wachirapan Supsahvad, Aylin Alasonyalilar-Demirer, Amanda R Panfil, Jingyu Xiang, Wessel P Dirksen, Deborah J Veis, Patrick L Green, Katherine N Weilbaecher and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of bone oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Nicole A KohartDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Said M ElshafaeDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Wachirapan SupsahvadDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Aylin Alasonyalilar-DemirerDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Amanda R PanfilDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jingyu XiangDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wessel P DirksenDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Deborah J VeisDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Patrick L GreenDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Katherine N WeilbaecherDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas J RosolDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USWashington University in St. Louis · USBursa Uludağ Üni̇versi̇tesi̇ · TROhio University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Role of Inflammation in Tax-mediated TumorigenesisP01CA100730 · NCI · WASHINGTON UNIVERSITY · PI Lee Ratner · 2003 to 2026
$44.8M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Mouse Pathobiology: Models of Human DiseaseT32OD010429 · OD · OHIO STATE UNIVERSITY · PI NIEWIESK, STEFAN, OGLESBEE, MICHAEL J · 2012 to 2017
$1.3M
NCI NIH HHS P01 CA100730NCI NIH HHS P30 CA016058NIAMS NIH HHS P30 AR074992NIH HHS T32 OD010429
6 · The paper itself

Abstract

Adult T-cell leukemia/lymphoma has a unique relationship to bone including latency in the marrow, and development of bone invasion, osteolytic tumors and humoral hypercalcemia of malignancy. To study these conditions, we established and characterized a novel mouse model of ATL bone metastasis. Patient-derived ATL cell lines including three that do not express HTLV-1 oncoprotein Tax (ATL-ED, RV-ATL, TL-Om1), an

Indexed as

ATL, adult T-cell leukemia/lymphomaBone resorptionHbz, HTLV-1 basic zipper proteinHHM, humoral hypercalcemia of malignancyHTLV-1HTLV-1, Human T-cell leukemia virus type 1LymphomaMetastasisMouse modelNK, natural killerNOD, non-obese diabeticNSG, NOD-scid IL2RgammanullqRT-PCR, quantitative real-time polymerase chain reactionSCID, CB17-PrkdcscidTax, transcriptional activator from the X regionμCT, micro-computed tomography

Identifiers

PMID31871882
PMCPMC6911918
OpenAlexW2969579399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.