Evidence map›Paper›PMID 31871866›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

Controlled Cellular Delivery of Amphiphilic Cargo by Redox-Responsive Nanocontainers.

Wilke C de Vries, Sergej Kudruk, David Grill, Maximilian Niehues, Anna Livia Linard Matos, Maren Wissing, Armido Studer, Volker Gerke, Bart Jan Ravoo

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Controlled Cellular Delivery of Amphiphilic Cargo by Redox-Responsive Nanocontainers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wilke C de VriesCenter for Soft Nanoscience and Organic Chemistry Institute Westfälische Wilhelms-Universität Münster Busso-Peus-Str. 10 Münster 48149 Germany.
Sergej KudrukInstitute of Medical Biochemistry Center for Molecular Biology of Inflammation Westfälische Wilhelms-Universität Münster Von-Esmarch-Str. 56 Münster 48149 Germany.
David GrillInstitute of Medical Biochemistry Center for Molecular Biology of Inflammation Westfälische Wilhelms-Universität Münster Von-Esmarch-Str. 56 Münster 48149 Germany.
Maximilian NiehuesCenter for Soft Nanoscience and Organic Chemistry Institute Westfälische Wilhelms-Universität Münster Busso-Peus-Str. 10 Münster 48149 Germany.
Anna Livia Linard MatosInstitute of Medical Biochemistry Center for Molecular Biology of Inflammation Westfälische Wilhelms-Universität Münster Von-Esmarch-Str. 56 Münster 48149 Germany.
Maren WissingCenter for Soft Nanoscience and Organic Chemistry Institute Westfälische Wilhelms-Universität Münster Busso-Peus-Str. 10 Münster 48149 Germany.
Armido StuderCenter for Soft Nanoscience and Organic Chemistry Institute Westfälische Wilhelms-Universität Münster Busso-Peus-Str. 10 Münster 48149 Germany.ORCID https://orcid.org/0000-0002-1706-513X
Volker GerkeInstitute of Medical Biochemistry Center for Molecular Biology of Inflammation Westfälische Wilhelms-Universität Münster Von-Esmarch-Str. 56 Münster 48149 Germany.ORCID https://orcid.org/0000-0001-7208-8206
Bart Jan RavooCenter for Soft Nanoscience and Organic Chemistry Institute Westfälische Wilhelms-Universität Münster Busso-Peus-Str. 10 Münster 48149 Germany.ORCID https://orcid.org/0000-0003-2202-7485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The specific transport of amphiphilic compounds such as fluorescently labeled phospholipids into cells is a prerequisite for the analysis of highly dynamic cellular processes involving these molecules, e.g., the intracellular distribution and metabolism of phospholipids. However, cellular delivery remains a challenge as it should not affect the physiological integrity and morphology of the cell membrane. To address this, polymer nanocontainers based on redox-responsive cyclodextrin (CD) amphiphiles are prepared, and their potential to deliver fluorescently labeled phospholipids to intracellular membrane compartments is analyzed. It is shown that mixtures of reductively degradable cyclodextrin amphiphiles and different phospholipids form liposome-like vesicles (CD-lipid vesicles, C

Indexed as

disulfidesintracellular deliverylipidsliposomespolymersself‐assembly

Identifiers

PMID31871866
PMCPMC6918114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.