ArticleJournal of ophthalmology2019
Increased Choroidal Thickness in Keratoconus Patients: Perspectives in the Disease Pathophysiology.
Article in Journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association of keratoconus with serum levels of 25-hydroxyvitamin D and antioxidant trace elements: A systematic review and meta-analysis.Indian journal of ophthalmology · 2022Pooled it
- Structural retinal and choroidal changes in keratoconus: A cross-sectional OCT study stratified by ABCD grading.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Observational
- Corneal Higher-Order Aberrations and Posterior Segment Changes in Keratoconus: A Multimodal OCT and OCTA Study.Diagnostics (Basel, Switzerland) · 2026Article
- Assessment of choroidal vascularity and thickness after corneal crosslinking treatment in keratoconus.BMC ophthalmology · 2026Article
- Macular Choroidal Thickness in Keratoconus: Systematic Review and Meta-Analysis of Current Evidence.Diagnostics (Basel, Switzerland) · 2025Review
- Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis.Heliyon · 2025Article
- Retinal neurovascular assessment and choroidal vascularity index in patients with keratoconus.Scientific reports · 2024Article
- Subfoveal choroidal thickness increases after excimer laser-assisted penetrating keratoplasty but not after excimer laser-assisted deep anterior lamellar keratoplasty.Scientific reports · 2024Article
- Serum inflammatory biomarkers are associated with increased choroidal thickness in keratoconus.Scientific reports · 2023Article
- Choroidal thickness assessment in keratoconus patients treated with cross-linking compared to healthy population.International ophthalmology · 2023Observational
- Assessment of the Retinal Vessels in Keratoconus: An OCT Angiography Study.Journal of clinical medicine · 2022Article
- Keratoconus enlargement as a predictor of keratoconus progression.Scientific reports · 2021Article
- The Role of Atopy in the Choroidal Profile of Keratoconus Patients.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Increased choroidal thickness is not a disease progression marker in keratoconus.Scientific reports · 2020Observational
- Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy Accompanied by Keratoconus.Ophthalmology scienceArticle
- Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?Journal of current ophthalmologyArticle
- Posterior segment alterations in keratoconus patients: an updated comprehensive review.Therapeutic advances in ophthalmologyReview
- Increased Choroidal Thickness in Morquio Syndrome.Case reports in ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze and compare choroidal thickness between keratoconus (KC) patients and age-matched non-KC subjects.
methodsA cross-sectional, case-control study. One hundred and thirty-four keratoconic eyes and 78 control eyes, from individuals aged from 12 to 30 years old, were studied. Patients with KC followed in Corneal Department of Centro Hospitalar São João, Porto, Portugal, were identified and consecutively included between December 2017 and February 2018. A spectral-domain optical coherence tomography (OCT) using depth enhanced imaging was performed, and choroidal thickness in the center of the fovea and at 500
resultsThe statistical analysis showed that keratoconic eyes present a thicker choroid in every measured location (
conclusionKeratoconus patients seem to have a thicker choroid than healthy individuals. The exact pathophysiological mechanism resulting in a thicker choroid in KC patients is not known, but it could possibly be associated with inflammatory choroidal mechanisms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.