Evidence map›Paper›PMID 31871534›Full record

ReviewThe World Allergy Organization journal2019

Challenges of managing food allergy in the developing world.

Elham Hossny, Motohiro Ebisawa, Yehia El-Gamal, Stefania Arasi, Lamia Dahdah, Rasha El-Owaidy, Cesar A Galvan, Bee Wah Lee, Michael Levin, Santiago Martinez and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Daily egg intake may reduce sensitisation to common allergenic foods among six- to nine-month-old south African infants: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Trial
  4. Trial
  5. Trial
  6. Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 8 countries.

Elham HossnyPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.
Yehia El-GamalPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Stefania ArasiPediatric Hospital Bambino Gesù, Vatican City, Italy.
Lamia DahdahPediatric Hospital Bambino Gesù, Vatican City, Italy.
Rasha El-OwaidyPediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Cesar A GalvanCentro Nacional de Referencia de Alergia Asma e Inmunología (CERNAAI), Instituto Nacional de Salud del Niño, Lima-Perú, Peru.
Bee Wah LeeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Michael LevinDivision Paediatric Allergology, University of Cape Town, Red Cross Children's Hospital, Cape Town, South Africa.
Santiago MartinezArnold Palmer Hospital for Children, Florida State University College of Medicine, Florida, United States.
Ruby PawankarDepartment of Pediatrics, Nippon Medical School, Tokyo, Japan.
Mimi L K TangDepartment of Allergy and Immunology, The Royal Children's Hospital, Melbourne, Australia.
Elizabeth H ThamDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Alessandro FiocchiPediatric Hospital Bambino Gesù, Vatican City, Italy.
Ain Shams University Hospital · EGBambino Gesù Children's Hospital · ITNational University of Singapore · SGFlorida State University · USInstituto Nacional de Salud del Niño · PENational Sagamihara Hospital · JPNippon Medical School · JPRoyal Children's Hospital · AUUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food allergy (FA) is currently a significant health care problem in the developing world. Widely varying study populations and methodologies, the use of surrogate markers such as self report or hospitalization rates due to anaphylaxis rather than objective methods, limits robust estimation of FA prevalence in low income settings. Also, allergy is under-recognized as a clinical specialty in the developing world which compromises the chance for accurate diagnosis. In this review, most published data on food allergens from developing or low income countries are displayed. The diagnostic challenges and limitations of treatment options are discussed. It seems that FA is an under-appreciated health care issue in the developing world, and accurate determination of its burden in low-income settings represents an important unmet need. Multicenter surveillance studies, using standardized methodologies, are, therefore, needed to reveal the true extent of the problem and provide epidemiological clues for prevention. Preventive strategies should be tailored to fit local circumstances in different geographic regions. In addition, studying the gene environment interactions and impact of early life microbiota on the expression of FA in developing communities would be worthwhile. Efforts and resources should be directed toward public health education and training of health care providers dealing with food allergic patients.

Indexed as

AllergensDeveloping countriesDiagnosisFood allergyLow incomeTreatmentUnmet needs

Identifiers

PMID31871534
PMCPMC6909084
OpenAlexW2994531390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.