Evidence map›Paper›PMID 31871532›Full record

ArticleThe World Allergy Organization journal2019

Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production.

Cong-Lin Liu, Guo-Ping Shi

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Long-Term PMAnnals of the American Thoracic Society · 2025
    Pooled it
  2. A Review of CXCL1 in Cardiac Fibrosis.Frontiers in cardiovascular medicine · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Research Progress on the Mechanisms of High Mucus Secretion in the Airway: A Scoping Review.International journal of chronic obstructive pulmonary disease · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Cong-Lin LiuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Guo-Ping ShiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and plays an essential role in goblet cell mucus production from the respiratory tract epithelium. CLCA1 also regulates Ca

Indexed as

AMCase, acidic mammalian chitinaseBALF, bronchoalveolar lavage fluidBpifa1, bactericidal/permeability-increasing protein (BPI) fold-containing family A member 1CaCCs, calcium-activated chloride channelscAMP, cyclic adenosine monophosphateCancerCeO2NPs, cerium dioxide nanoparticlesCF, cystic fibrosisCFTR, cystic fibrosis transmembrane conductance regulatorCLCA1CLCA1, calcium-activated chloride channel regulator 1COPD, chronic obstructive pulmonary diseaseCXCL-1, C-X-C motif chemokine ligand 1DOG1, discovered on gastrointestinal stromal tumours-1DSS, dextran sodium sulfateEGFR, epidermal growth factor receptorEMT, epithelial-mesenchymal transitionEpOCs, epithelial organoid culturesERK, extracellular signal-regulated kinaseFAK, focal adhesion kinaseGastrointestinal diseaseGob-5, goblet cell protein-5HDMA, house dust mite allergenIAD, inflammatory airway diseasesInnate immunityKCNMB1, potassium calcium-activated channel subfamily M regulatory beta subunit 1LFA-1, lymphocyte function-associated antigen 1.LFC, log2 fold changeMUC5AC, mucin 5ACMucinNFA, niflumic acidOVA, ovalbuminRespiratory diseasesrIFABP, rat intestinal fatty acid binding protein promoterSPDEF, sterile alpha motif [SAM] domain-containing prostate-derived Ets transcription factorSTAT6, signal transducer and activator of transcription 6TMEM16A, transmembrane protein 16ATNF-α, tumor necrosis factor-αVWA, von Willebrand factor type AWT, wild-typeβ4BMs, β4-binding motifs

Identifiers

PMID31871532
PMCPMC6909348
OpenAlexW2989878698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.