ArticleInternational journal of endocrinology2019
Dysregulation of Kisspeptin and Leptin, as Anorexigenic Agents, Plays Role in the Development of Obesity in Postmenopausal Women.
Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Eating Behavior in Menopausal Women: From Molecular to Clinical Aspects-What Changes?International journal of molecular sciences · 2026Review
- Gestational diabetes mellitus-induced adipokine dysregulation and links to metabolic programming risks.Frontiers in endocrinology · 2026Observational
- Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.Cell biochemistry and biophysics · 2025Review
- A review on impact of adipocytokines in post postmenopausal women.Bioinformation · 2025Article
- Comparison of leptin and estrone levels between normal body mass index and obese menopausal women.Narra J · 2024Article
- The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome.Reviews in endocrine & metabolic disorders · 2024Review
- A longitudinal study of free leptin index in pre-eclamptic pregnancies.Journal of cellular and molecular medicine · 2023Observational
- Serum Level of Inhibin B and Kisspeptin, as well as Their Correlation with Biochemical Factors in Obese Adult Patients.Archives of Razi Institute · 2022Article
- Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding.Pharmacology & therapeutics · 2022Review
- Growth Hormone (GH) Treatment Decreases Plasma Kisspeptin Levels in GH-Deficient Adults with Prader-Willi Syndrome.Journal of clinical medicine · 2021Article
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children.International journal of endocrinology · 2020Article
- Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys.Androgens: clinical research and therapeutics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the menopausal period, women have a higher tendency to develop obesity and any other metabolic syndromes. Dysregulation of leptin and kisspeptin signaling as anorexigenic agents is believed to be the connection between metabolic disorders and altered reproductive function. Therefore, this study aimed at investigating the association between leptin, soluble leptin receptor (sOBR), free leptin index, kisspeptin concentrations, and body mass index (BMI) in postmenopausal women. A cross-sectional study was carried out among 171 postmenopausal women aged 40-75 years from 2017 to 2018. Subjects were assigned into 2 groups according to their BMIs: obese group (84 subjects) and nonobese group (87 subjects). In addition to anthropometric measurement, blood sample was collected from each subject for leptin, sOBR, free leptin index (FLI), and kisspeptin evaluation. Bivariate and correlation analysis discovered that leptin and FLI were positively correlated with BMI, while sOBR and kisspeptin were negatively correlated with BMI. Among those variables, multivariate analysis found that leptin, sOBR, and kisspeptin were independently associated with obesity. Therefore, it can be concluded that higher serum leptin concentration and FLI, as well as lower serum sOBR and kisspeptin concentrations, are significantly associated with obesity in postmenopausal women.
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Registered trials
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