Evidence map›Paper›PMID 31871427›Full record

ArticleMediators of inflammation2019

The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity.

Yujia Li, Max Xuezhong Ma, Bo Qin, Liang-Tzung Lin, Christopher D Richardson, Jordan Feld, Ian D McGilvray, Limin Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Yujia LiInstitute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu, Sichuan 610052, China.ORCID https://orcid.org/0000-0002-2636-5468
Max Xuezhong MaToronto General Research Institute, University of Toronto, Toronto, Ontario, Canada M5S 1A1.
Bo QinDepartment of Infectious Diseases, The 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liang-Tzung LinDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-7374-7234
Christopher D RichardsonDepartment of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.
Jordan FeldToronto General Research Institute, University of Toronto, Toronto, Ontario, Canada M5S 1A1.ORCID https://orcid.org/0000-0003-2640-2211
Ian D McGilvrayToronto General Research Institute, University of Toronto, Toronto, Ontario, Canada M5S 1A1.ORCID https://orcid.org/0000-0003-4649-546X
Limin ChenInstitute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu, Sichuan 610052, China.ORCID https://orcid.org/0000-0002-7370-6499
University of Toronto · CAChinese Academy of Medical Sciences & Peking Union Medical College · CNChongqing Medical University · CNDalhousie University · CATaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsUbiquitin-specific protease 18 (USP18) is involved in immunoregulation and response to interferon- (IFN-) based treatment in patients chronically infected with hepatitis C virus (HCV). We investigated whether and how its upregulation alters HCV infection.

methodsOverexpression of wild-type (USP18 WT) or catalytically inactive mutant (USP18 C64S) USP18 was examined for effects on HCV replication in the absence and presence of IFN

resultsWe found that overexpression of either USP18 WT or USP18 C64S stimulated HCV production and blunted the anti-HCV effect of IFN

conclusionsUSP18 stimulates HCV production and blunts the effect of both type I and III IFNs by fostering a cellular environment characterized by upregulation of CD81, promoting virus entry and infectivity.

Indexed as

Cell LineHepacivirusHumansMicroRNAsPlasmidsTetraspanin 28Ubiquitin-Specific ProteasesUbiquitin ThiolesteraseMicroRNAsMIRN122 microRNA, humanTetraspanin 28Ubiquitin-Specific ProteasesUbiquitin ThiolesteraseUSP18 protein, human

Identifiers

PMID31871427
PMCPMC6906844
OpenAlexW2987956026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.