ArticleNature cell biology2020
Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development.
Article in Nature cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells.PLoS genetics · 2025Article
- FHL2 fused with biotin ligase shuttles between focal adhesions and the nucleus in a myosin II-dependent manner.microPublication biology · 2025Article
- Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals.eLife · 2023Article
- Advanced Techniques Using In Vivo Electroporation to Study the Molecular Mechanisms of Cerebral Development Disorders.International journal of molecular sciences · 2023Review
- AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis.eLife · 2023Article
- Editorial: Marine invertebrates: neurons, glia, and neurotransmitters.Frontiers in neural circuits · 2023Article
- Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling.Nature cell biology · 2022Article
- RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination.EMBO reports · 2022Article
- Cortical Organoids to Model Microcephaly.Cells · 2022Review
- Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.Neuron · 2022Review
- Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.Nature communications · 2022Article
- The Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain.Frontiers in cell and developmental biology · 2022Review
- Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution.Development (Cambridge, England) · 2021Article
- Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.eLife · 2021Article
- Article
- Delta-Notch Signaling: The Long and The Short of a Neuron's Influence on Progenitor Fates.Journal of developmental biology · 2020Review
- Neuronal Delamination and Outer Radial Glia Generation in Neocortical Development.Frontiers in cell and developmental biology · 2020Review
- Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies.Frontiers in pharmacology · 2020Review
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural stem cells, called radial glia, maintain epithelial structure during the early neocortical development. The prevailing view claims that when radial glia first proliferate, their symmetric divisions require strict spindle orientation; its perturbation causes precocious neurogenesis and apoptosis. Here, we show that despite this conventional view, radial glia at the proliferative stage undergo normal symmetric divisions by regenerating an apical endfoot even if it is lost by oblique divisions. We found that the Notch-R-Ras-integrin β1 pathway promotes the regeneration of endfeet, whose leading edge bears ectopic adherens junctions and the Par-polarity complex. However, this regeneration ability gradually declines during the subsequent neurogenic stage and hence oblique divisions induce basal translocation of radial glia to form the outer subventricular zone, a hallmark of the development of the convoluted brain. Our study reveals that endfoot regeneration is a temporally changing cryptic property, which controls the radial glial state and its shift is essential for mammalian brain size expansion.
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