Evidence map›Paper›PMID 31871241›Full record

ReviewCold Spring Harbor perspectives in medicine2020

Experimental Approaches to Identify Host Factors Important for Influenza Virus.

Grace A Schaack, Andrew Mehle

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Grace A SchaackDepartment of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA.
Andrew MehleDepartment of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA.ORCID 0000-0001-6060-4330

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Regulation of the influenza virus polymeraseR01AI125271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MEHLE, ANDREW · 2016 to 2020
$1.9M
Identifying host factors and the mechanisms used to control influenza virus replicationR21AI125897 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MEHLE, ANDREW · 2016 to 2017
$425k
NIAID NIH HHS R01 AI125271NIAID NIH HHS R21 AI125897NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

An ever-expanding toolkit of experimental methods provides the means to discover and characterize host factors important for influenza virus. Here, we describe common methods for investigating genetic relationships and physical interactions between virus and host. A comprehensive knowledge of host:virus interactions is key to understanding how influenza virus exploits the host cell and to potentially identify vulnerabilities that may be manipulated to prevent or treat disease.

Indexed as

Host-Pathogen InteractionsOrthomyxoviridaeGene Expression ProfilingGene Knockout TechniquesHumansInfluenza, HumanPolymorphism, Single NucleotideRNA InterferenceVirus Replication

Identifiers

PMID31871241
PMCPMC7706581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.