Evidence map›Paper›PMID 31871218›Full record

Observational studyNeurology2020

Longitudinal change in regional brain volumes with exposure to repetitive head impacts.

Charles Bernick, Guogen Shan, Henrik Zetterberg, Sarah Banks, Virendra R Mishra, Lynn Bekris, James B Leverenz, Kaj Blennow

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  4. Factors associated with subjective cognitive complaints in former American football players.Journal of the International Neuropsychological Society : JINS · 2026
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  16. Repeated Sub-Concussive Impacts and the Negative Effects of Contact Sports on Cognition and Brain Integrity.International journal of environmental research and public health · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Charles BernickFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH. bernicc@ccf.org.
Guogen ShanFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
Henrik ZetterbergFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
Sarah BanksFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
Virendra R MishraFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.ORCID 0000-0002-0452-6400
Lynn BekrisFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
James B LeverenzFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
Kaj BlennowFrom the Cleveland Clinic (C.B., V.R.M.), Las Vegas; University of Nevada (G.S.), Las Vegas; Sahlgrenska Academy (H.Z., K.B.), University of Gothenburg, Sweden; University of California (S.B.), San Diego; and Cleveland Clinic (L.B., J.B.L.), OH.
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study tests the hypothesis that certain MRI-based regional brain volumes will show reductions over time in a cohort exposed to repetitive head impacts (RHI).

methodsParticipants were drawn from the Professional Fighters Brain Health Study, a longitudinal observational study of professional fighters and controls. Participants underwent annual 3T brain MRI, computerized cognitive testing, and blood sampling for determination of neurofilament light (NfL) and tau levels. Yearly change in regional brain volume was calculated for several predetermined cortical and subcortical brain volumes and the relationship with NfL and tau levels determined.

resultsA total of 204 participants who had at least 2 assessments were included in the analyses. Compared to controls, the active boxers had an average yearly rate of decline in volumes of the left thalamus (102.3 mm

conclusionVolumetric loss in different brain regions may reflect different pathologic processes at different times among individuals exposed to RHI.

Indexed as

AdultBoxingBrainFemaleHead Injuries, ClosedHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID31871218
PMCPMC7108810
OpenAlexW2996964463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.